Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy
Journal
Lung Cancer
Journal Volume
59
Journal Issue
1
Pages
105-110
Date Issued
2008
Author(s)
Abstract
Caveolin-1 was up-regulated in different drug-resistant cancer cell lines and was suggested to confer drug resistance by different mechanisms. However, the relation of caveolin-1 expression and the clinical response to chemotherapy and prognosis in non-small cell lung cancer (NSCLC) remains unknown. Total 73 NSCLC (stages IIIB and IV) patients who received gemcitabine-based chemotherapy and also had tumour specimens available before treatment were assessed for caveolin-1 expression using immunohistochemistry. Immunoreactivity of caveolin-1 was correlated with the response to chemotherapy, the clinicopathologic features, and the progression-free survival (PFS) and overall survival (OS) of all patients. Positive caveolin-1 immunostaining was found in 12 (16.4%) of the 73 patients. Eight of the twelve had disease progression and the other four patients remained stable after chemotherapy. Patients with caveolin-1 expression had a significantly lower response rate (complete or partial response, 0% versus 37.7%; P = 0.01) and a poor PFS and OS (median survival time: PFS, 4.6 months versus 6.1 months, P = 0.005; OS, 7.0 months versus 14 months, P < 0.001) than those without caveolin-1 expression. Moreover, multivariate analyses indicated that caveolin-1 positivity was an independent prognostic factor for disease-free survival (DFS) (P = 0.003) and OS (P = 0.008), respectively. Caveolin-1 expression significantly correlated with drug resistance and a poor prognosis in advanced NSCLC patients treated with gemcitabine-based chemotherapy. ? 2007 Elsevier Ireland Ltd. All rights reserved.
SDGs
Other Subjects
caveolin 1; cisplatin; epirubicin; gemcitabine; adult; advanced cancer; aged; article; cancer combination chemotherapy; cancer survival; combination chemotherapy; drug response; female; human; human tissue; immunohistochemistry; lung non small cell cancer; major clinical study; male; monotherapy; multiple cycle treatment; overall survival; priority journal; prognosis; protein expression; treatment outcome; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caveolin 1; Deoxycytidine; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis
Type
journal article