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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/470970
Title: Prognostic significance of adipocytokines in systolic heart failure patients
Authors: Wu X.-M.
Lin Y.-H.
Chen A.
Hsu T.-P.
Wu Y.-W.
Lin H.-J.
Hsu R.-B.
Lee C.-M.
SHOEI-SHEN WANG 
Lo M.-T.
Ho Y.-L.
Chen M.-F.
Issue Date: 2012
Journal Volume: 42
Journal Issue: 10
Start page/Pages: 1079-1086
Source: European Journal of Clinical Investigation
Abstract: 
Objectives The goal of this study was designed to assess prognostic values of simultaneous measurement of adipocytokines in systolic heart failure (HF) patients. Methods Patients with HF manifestations and left ventricular ejection fraction (LVEF)?50% were selected in this study. Gender, age, medications and serum biochemical data were recorded upon admissions. Adipocytokines including adiponectin, leptin, resistin, visfatin and retinol binding protein-4 were measured. Results A total of 108 (83 males and 25 females) patients were enroled. The age was 62±15years and mean LVEF was 35%. Twenty patients died during 776±323days follow-up. In univariate analysis, mortality was found to be associated with the log-transformed values of serum resistin (β=5·616, P=0·04), log-transformed values of serum adiponectin (β=4·377, P=0·038), age (β=1·071, P<0·001), NTHA functional status (β=3·752, P=0·001) and body mass index (β=0·858, P=0·012). Patients with higher level of serum resistin were associated with higher mortality (P=0·012). In multivariate analysis, mortality is associated with log-transformed values of serum resistin (β=3·666, P=0·045), age (β=1·044, P=0·017) and NTHA functional status (β=2·541, P=0·025). Conclusions Serum resistin level was associated with higher mortality in systolic HF patients even after adjusting clinical parameters. Resistin may be an informative risk marker for systolic HF patients. ? 2012 The Authors. European Journal of Clinical Investigation ? 2012 Stichting European Society for Clinical Investigation Journal Foundation.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866280411&doi=10.1111%2fj.1365-2362.2012.02698.x&partnerID=40&md5=b71f7b7d51028e051487ead50195427d
https://scholars.lib.ntu.edu.tw/handle/123456789/470970
ISSN: 0014-2972
DOI: 10.1111/j.1365-2362.2012.02698.x
metadata.dc.subject.other: adiponectin; leptin; nicotinamide phosphoribosyltransferase; resistin; retinol binding protein 4; adult; aged; article; body mass; controlled study; female; follow up; functional status; heart left ventricle ejection fraction; human; major clinical study; male; mortality; priority journal; prognosis; systolic heart failure; Adipokines; Biological Markers; Chronic Disease; Female; Heart Failure, Systolic; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Risk Factors; Ventricular Dysfunction, Left
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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