https://scholars.lib.ntu.edu.tw/handle/123456789/471015
Title: | The relationship between aminoterminal propeptide of type III procollagen and heart rate variability parameters in heart failure patients: A potential serum marker to evaluate cardiac autonomic control and sudden cardiac death | Authors: | YEN-HUNG LIN Lin C. Lo M.-T. HUNG-JU LIN YEN-WEN WU RON-BIN HSU CHIA-LUN CHAO Hsu H.-C. Wang P.-C. VIN-CENT WU SHOEI-SHEN WANG CHII-MING LEE KUO-LIONG CHIEN YI-LWUN HO MING-FONG CHEN Peng C.-K. |
Issue Date: | Dec-2010 | Journal Volume: | 48 | Journal Issue: | 12 | Start page/Pages: | 1821-1827 | Source: | Clinical Chemistry and Laboratory Medicine | Abstract: | Background: Cardiac extra-cellular matrix (ECM) fibrosis plays an important role in the pathophysiology of heart failure (HF). It may provide electrical heterogeneity and a substrate for arrhythmogenicity, which may cause sudden cardiac death (SCD). Methods: Twenty-one patients with manifestations of HF and a left ventricular ejection fraction (LVEF) ?50% were enrolled. The median age was 62 years and median LVEF was 33%. Time- and frequency-domain analysis of heart rate variability (HRV) on 24 h ambulatory electrocardiography recording was assessed. Serum markers of ECM turnover including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed. Results: The serum PIIINP concentration was correlated significantly with standard deviation of all normal to normal R-R intervals (SDNN) (r=-0.722, p=<0.001), percentage of adjacent NN interval differences >50 ms (pNN50) (r=-0.528, p=0.014), percentage of adjacent NN interval differences >20 ms (pNN20) (r=-0.545, p=0.002), very low frequency (VLF) (r=-0.490, p=0.024), low frequency (LF) (r=-0.491, p=0.024), and high frequency (HF) (r=-0.513, p=0.018). PINP, MMP-2, -9, TIMP-1 were not correlated with time- and frequency-domain analysis of HRV. Conclusions: PIIINP was significantly correlated with time- and frequency-domain analysis of HRV in HF patients. PIIINP is a potential serological marker to evaluate cardiac autonomic control and risk of SCD in HF patients. ? 2010 by Walter de Gruyter Berlin New York. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79251510542&doi=10.1515%2fCCLM.2010.348&partnerID=40&md5=12ce4454f5ca3b2d37a6491ff074054b https://scholars.lib.ntu.edu.tw/handle/123456789/471015 |
ISSN: | 1434-6621 | DOI: | 10.1515/CCLM.2010.348 | SDG/Keyword: | angiotensin receptor antagonist; beta adrenergic receptor blocking agent; digoxin; dipeptidyl carboxypeptidase inhibitor; loop diuretic agent; procollagen type 3 aminopropeptide; spironolactone; adult; aged; article; clinical article; disease marker; electrocardiography; extracellular matrix; female; heart failure; heart function; heart left ventricle ejection fraction; heart rate variability; human; male; priority journal; protein blood level; sudden death; Autonomic Nervous System; Biological Markers; Collagen Type III; Death, Sudden, Cardiac; Electrocardiography, Ambulatory; Extracellular Matrix; Female; Heart Failure; Heart Rate; Humans; Male; Middle Aged |
Appears in Collections: | 醫學系 |
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