https://scholars.lib.ntu.edu.tw/handle/123456789/471034| Title: | Prognostic significance of adipocytokines and extracellular matrix activity in heart failure patients with high B-type natriuretic peptide | Authors: | Ho Y.-L. Lin Y.-H. Lee C.-M. Hsu R.-B. Ting H.-T. Chou N.-K. Chao C.-L. SHOEI-SHEN WANG Hsu H.-C. Chen M.-F. |
Issue Date: | 2009 | Journal Volume: | 42 | Journal Issue: | 13-14 | Start page/Pages: | 1407-1412 | Source: | Clinical Biochemistry | Abstract: | Objectives: To perform risk stratification by serum adipocytokines and serum markers of extracellular matrix in heart failure patients with high b-type natriuretic peptide (BNP). Methods: Patients with heart failure were enrolled in this study. Serum adipocytokines and serum markers of extracellular matrix were analyzed. Results: In total, 131 patients were enrolled and followed-up for 240 ± 174?days. Mortality was significantly associated with adiponectin, resistin, type III amioterminal propeptide of procollagen (PIIINP), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase 1 (TIMP-1), and serum creatinine. Heart failure-related admission was significantly associated with apelin, and PIIINP. Cox regression analysis identified that mortality and heart failure-related admissions were significantly associated with MMP-2 (P = 0.008) and PIIINP (P = 0.011), respectively. Conclusions: Serum markers of extracellular matrix rather than adipocytokines may warrant further risk stratification for impacting the prognosis of patients with heart failure with high BNP. ? 2009 The Canadian Society of Clinical Chemists. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-69249229547&doi=10.1016%2fj.clinbiochem.2009.06.013&partnerID=40&md5=00df3c777699c941d092340b69f422a5 https://scholars.lib.ntu.edu.tw/handle/123456789/471034 |
ISSN: | 0009-9120 | DOI: | 10.1016/j.clinbiochem.2009.06.013 | metadata.dc.subject.other: | adipocytokine; adiponectin; angiotensin receptor antagonist; apelin; beta adrenergic receptor blocking agent; brain natriuretic peptide; creatinine; digoxin; dipeptidyl carboxypeptidase inhibitor; gelatinase A; loop diuretic agent; procollagen type 3 aminopropeptide; resistin; spironolactone; tissue inhibitor of metalloproteinase 1; adult; article; extracellular matrix; female; follow up; heart atrium fibrillation; heart failure; heart ventricle tachycardia; hospital admission; human; laboratory test; major clinical study; male; mortality; priority journal; prognosis; protein analysis; protein blood level; Adipokines; Adiponectin; Aged; Creatinine; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Female; Heart Failure; Humans; Kaplan-Meiers Estimate; Linear Models; Male; Matrix Metalloproteinase 2; Middle Aged; Multivariate Analysis; Natriuretic Peptide, Brain; Peptide Fragments; Procollagen; Prognosis; Proportional Hazards Models; Resistin; Tissue Inhibitor of Metalloproteinase-1 [SDGs]SDG3 |
| Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.