Intravascular Ultrasound Evidence of Angiographically Silent Allograft Vasculopathy Inversely Correlates With Circulating Level of Hepatocyte Growth Factor
Journal
Journal of Heart and Lung Transplantation
Journal Volume
25
Journal Issue
12
Pages
1456-1461
Date Issued
2006
Author(s)
Abstract
Background: Cardiac allograft vasculopathy (CAV) is the major determinant of long-term survival after heart transplantation. The characteristic diffuse concentric intimal thickening of CAV detected by intravascular ultrasound (IVUS) imaging may not be perceivable on coronary angiogram. Previous studies of hepatocyte growth factor (HGF) in murine models suggested the protective effects on vascular endothelium and allograft survival. However, the possible role of circulating HGF that contributes to the development of CAV in human is unclear. Methods: IVUS was used to assess the left anterior descending coronary arteries of 47 patients who had survived cardiac transplantation for more than 1 year and had no angiographically detectable CAV. The IVUS measurements for the extent of intimal hyperplasia, including volume index (calculated as [total plaque volume/total vessel volume] × 100) and maximum area stenosis, were compared with plasma levels of HGF by linear regression analyses. Results: The volume index significantly correlated with maximum area stenosis in the IVUS measurements (r = 0.90, p < 0.0001). Both volume index and maximum area stenosis inversely correlated with plasma HGF levels (r = -0.39, p = 0.007 and r = -0.42, p = 0.003, respectively). Conclusions: In angiographically silent CAV, circulating HGF may have a protective effect on vascular endothelium and thus attenuate the severity of intimal hyperplasia. ? 2006 International Society for Heart and Lung Transplantation.
SDGs
Other Subjects
dipeptidyl carboxypeptidase inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; immunosuppressive agent; scatter factor; adult; angiocardiography; artery intima proliferation; article; cardiac allograft vasculopathy; cardiac graft rejection; clinical article; controlled study; correlation analysis; female; graft survival; heart transplantation; human; intravascular ultrasound; left anterior descending coronary artery; linear regression analysis; male; priority journal; statistical significance; vascular endothelium; Adult; Aged; Coronary Angiography; Coronary Disease; Female; Heart Transplantation; Hepatocyte Growth Factor; Humans; Male; Middle Aged; Ultrasonography, Interventional
Type
journal article