Value of circulating adhesion molecules in assessing cardiac allograft vasculopathy
Journal
Journal of Heart and Lung Transplantation
Journal Volume
22
Journal Issue
11
Pages
1284-1287
Date Issued
2003
Author(s)
Abstract
Circulating adhesion molecules have been implicated in the development of spontaneous and transplant coronary artery disease. We analyzed soluble (s) intercellular adhesion molecule 1 (sICAM-1), vascular cell adhesion molecule 1 (sVCAM-1), and sE-selectin levels from the coronary sinuses of 25 cardiac allograft recipients, and we correlated these molecules with the degree of acute rejection detected in endomyocardial biopsy specimens and the presence of transplant vasculopathy assessed with coronary angiography. We found that sVCAM-1 significantly increased in patients with transplant vasculopathy compared with those without transplant vasculopathy, whereas sE-selectin and sICAM-1 did not. Therefore, increased coronary sinus levels of sVCAM-1 is a reliable marker in assessing cardiac transplant vasculopathy.
SDGs
Other Subjects
biological marker; endothelial leukocyte adhesion molecule 1; intercellular adhesion molecule 1; vascular cell adhesion molecule 1; acute graft rejection; adult; article; clinical article; controlled study; coronary sinus; correlation analysis; female; follow up; heart muscle biopsy; heart transplantation; human; human tissue; male; priority journal; protein blood level; protein localization; statistical significance; tissue distribution
Publisher
Elsevier Inc.
Type
journal article