Differential lipogenic effects of cilostazol and pentoxifylline in patients with intermittent claudication: Potential role for interleukin-6
Journal
Atherosclerosis
Journal Volume
158
Journal Issue
2
Pages
471
Date Issued
2001
Author(s)
Abstract
Cilostazol, a novel oral phosphodiesterase inhibitor, has shown consistent improvement in exercise tolerance in patients with intermittent claudication (IC). In addition to this effect, cilostazol has previously been shown to have beneficial effects on the dyslipidemia, i.e., combination of high triglycerides with low high-density-lipoprotein cholesterol (HDL-C) levels. Interluekin-6 (IL-6) suppresses the activity of lipoprotein lipase, which modulates the metabolism of triglycerides and HDL-C. To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC. After eight weeks of administration of cilostazol to patients with IC, walking distances were increased, associated with a 29% decrease in plasma triglycerides and a 13% increase in HDL-C. No significant changes of lipid profiles in the pentoxifylline and placebo groups were observed although a similar improvement in walking distances was achieved in the pentoxifylline group. IL-6 levels were significantly reduced in patients receiving cilostazol as compared with those receiving placebo or pentoxifylline. The cilostazol-induced changes in the IL-6 were positively related to those of triglycerides in the cilostazol group (r=0.63, P<0.05) and negatively related to those of HDL-C (r=-0.55, P<0.05). These findings suggest that in addition to consistent improvement of exercise tolerance, cilostazol may improve lipid profiles by reducing IL-6 release. However, pentoxifylline did not affect lipid profiles although a similar improvement of maximal walking distance (MWD) was achieved. ? 2001 Elsevier Science Ireland Ltd. All rights reserved.
SDGs
Other Subjects
cilostazol; high density lipoprotein cholesterol; interleukin 6; lipid; pentoxifylline; placebo; triacylglycerol; adult; aged; article; cholesterol blood level; clinical article; clinical trial; controlled clinical trial; controlled study; cytokine release; dose time effect relation; double blind procedure; drug effect; drug potency; exercise tolerance; female; human; intermittent claudication; lipogenesis; male; peripheral occlusive artery disease; priority journal; protein blood level; randomized controlled trial; treadmill exercise; treatment outcome; triacylglycerol blood level; walking; Aged; Antilipemic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Interleukin-6; Intermittent Claudication; Lipids; Male; Pentoxifylline; Phosphodiesterase Inhibitors; Prospective Studies; Tetrazoles; Triglycerides; Vasodilator Agents
Type
journal article