Biological significance of TERT promoter mutation in papillary urothelial neoplasm of low malignant potential
Journal
Histopathology
Journal Volume
72
Journal Issue
5
Pages
795-803
Date Issued
2018
Author(s)
Abstract
Aims: Mutations in FGFR3 and the promoter region of the telomerase reverse transcriptase (TERT) gene have been found frequently in urothelial carcinoma of the urinary bladder. However, related data for papillary urothelial neoplasm of low malignant potential (PUNLMP) are limited. In this study, we investigated the mutation status of the TERT promoter, FGFR3 and HRAS in low-grade papillary urothelial neoplasms and evaluated their prognostic significance. Methods and results: The cases included in this study comprised 21 inverted papillomas, 30 PUNLMPs and 34 low-grade non-invasive papillary urothelial carcinomas (NIPUCs). TERT promoter mutations were observed in 10 (33%) PUNLMPs and 17 (50%) low-grade NIPUCs, but not in any inverted papilloma. FGFR3 mutations were observed more frequently in PUNLMP and low-grade NIPUC than in inverted papillomas (P?=?0.009), whereas the opposite trend was noted for HRAS mutations (P?
SDGs
Other Subjects
fibroblast growth factor receptor 3; telomerase reverse transcriptase; FGFR3 protein, human; fibroblast growth factor receptor 3; HRAS protein, human; protein p21; telomerase; TERT protein, human; tumor marker; adult; aged; Article; bladder tumor; cancer prognosis; carcinogenesis; clinical feature; DNA sequence; female; gene mutation; gene targeting; human; human tissue; inverted papilloma; major clinical study; male; mutation rate; non invasive papillary urothelial carcinoma; oncogene H ras; papilloma; priority journal; promoter region; recurrence free survival; recurrence risk; transitional cell carcinoma; tumor growth; urinary bladder papillary urothelial neoplasm of low malignant potential; very elderly; bladder tumor; genetics; Kaplan Meier method; middle aged; mutation; papillary carcinoma; pathology; promoter region; tumor recurrence; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Papillary; Carcinoma, Transitional Cell; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mutation; Neoplasm Recurrence, Local; Papilloma, Inverted; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); Receptor, Fibroblast Growth Factor, Type 3; Telomerase; Urinary Bladder Neoplasms
Publisher
Blackwell Publishing Ltd
Type
journal article