Input of microenvironmental regulation on colorectal cancer: Role of the CCN family
Journal
World Journal of Gastroenterology
Journal Volume
20
Journal Issue
22
Pages
6826-6831
Date Issued
2014
Author(s)
Abstract
Colorectal cancer (CRC) is a major health problem causing significant morbidity and mortality. Previous results from various studies indicate that CRC tumorigenicity encompasses tumor microenvironment, emphasizing the complex interacting network between cancer cells and nearby host cells, which triggers diverse signaling pathways to promote the growth and spread of cancer cells. The CCN family proteins share a uniform modular structure, mediating a variety of physiological functions, including proliferation, apoptosis, migration, adhesion, differentiation, and survival. Furthermore, CCN proteins are also involved in CRC initiation and development. Many studies have shown that CCN members, such as CCN1, CCN2, CCN3, Wnt-induced secreted protein (WISP)-1, WISP-2, and WISP-3, are dysregulated in CRC, which implies potential diagnostic markers or therapeutic targets clinically. In this review, we summarize the research findings on the role of CCN family proteins in CRC initiation, development, and progression, highlighting their potential for diagnosis, prognosis, and therapeutic application. ? 2014 Baishideng Publishing Group Inc. All rights reserved.
SDGs
Other Subjects
CCN protein; ccn4 protein; ccn5 protein; ccn6 protein; connective tissue growth factor; cyclin D1; cyclooxygenase 2; cysteine rich protein 61; epidermal growth factor; insulin; integrin; interleukin 1; interleukin 6; matrilysin; nephroblastoma overexpressed protein; Notch receptor; peptides and proteins; Ras protein; somatomedin binding protein; sonic hedgehog protein; thrombospondin; transforming growth factor alpha; transforming growth factor beta; tumor necrosis factor alpha; unclassified drug; unindexed drug; von Willebrand factor; Wnt induced secreted protein 1; Wnt induced secreted protein 2; Wnt induced secreted protein 3; Wnt protein; antineoplastic agent; CCN protein; tumor marker; apoptosis; cancer growth; cell adhesion; cell differentiation; cell migration; cell proliferation; cell survival; colorectal cancer; epigenetics; human; protein expression; review; signal transduction; tumor microenvironment; tumor suppressor gene; animal; Colorectal Neoplasms; disease course; drug design; metabolism; molecularly targeted therapy; pathology; Animals; Antineoplastic Agents; CCN Intercellular Signaling Proteins; Colorectal Neoplasms; Disease Progression; Drug Design; Humans; Molecular Targeted Therapy; Signal Transduction; Tumor Markers, Biological; Tumor Microenvironment
Publisher
WJG Press
Type
review