Expression of LEF1 is an independent prognostic factor for patients with oral squamous cell carcinoma
Journal
Journal of the Formosan Medical Association
Journal Volume
113
Journal Issue
12
Pages
934-939
Date Issued
2014
Author(s)
Abstract
Background/Purpose: Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LEF1 in 135 cases of OSCC were determined by immunohistochemistry. The results were correlated with clinicopathologic parameters and patient outcome. Results: LEF1 was only occasionally detected in basal and parabasal cells of nontumorous squamous epithelium. Overexpression of LEF1 was observed in 33 of 135 OSCCs (24%). LEF1 was more frequently expressed in moderately to poorly differentiated cancer (. p=0.0035) and was associated with lymphovascular invasion (. p=0.0252). Overexpression of LEF1 was significantly associated with poor prognosis (. p=0.0176, hazard ratio=1.96, 95% CI=1.02-3.75). Multivariate analysis revealed LEF1expression and margin status to be the significant independent predictors for overall survival. Conclusion: Our study suggests LEF1 expression in OSCC may play an important role in tumor progression and can be served as a predictor of poor prognosis for patients with OSCC. ? 2013.
Other Subjects
lymphoid enhancer factor 1; LEF1 protein, human; lymphoid enhancer factor 1; adult; Article; cancer patient; cancer prognosis; controlled study; female; histopathology; human; human tissue; immunohistochemistry; lymph vessel metastasis; major clinical study; male; mouth squamous cell carcinoma; nucleotide sequence; overall survival; protein expression; tumor growth; cancer grading; Carcinoma, Squamous Cell; chemistry; middle aged; minimal residual disease; Mouth Neoplasms; pathology; prognosis; survival rate; tumor invasion; Carcinoma, Squamous Cell; Female; Humans; Lymphoid Enhancer-Binding Factor 1; Male; Middle Aged; Mouth Neoplasms; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm, Residual; Prognosis; Survival Rate
Publisher
Elsevier
Type
journal article