https://scholars.lib.ntu.edu.tw/handle/123456789/473398
標題: | Viral hepatitis is associated with intrahepatic cholangiocarcinoma with cholangiolar differentiation and N-cadherin expression | 作者: | Yu T.-H. RAY-HWANG YUAN Chen Y.-L. Yang W.-C. Hsu H.-C. YUNG-MING JENG |
公開日期: | 2011 | 卷: | 24 | 期: | 6 | 起(迄)頁: | 810-819 | 來源出版物: | Modern Pathology | 摘要: | Viral hepatitis-associated intrahepatic cholangiocarcinoma is thought to have common disease processes with hepatocellular carcinoma, but until now the histomorphological and genetic features of viral hepatitis-associated intrahepatic cholangiocarcinoma is still unknown. From 2000 to 2010, 170 patients with intrahepatic cholangiocarcinoma who received detailed pathological assessment and regular follow-up at the National Taiwan University Hospital were selected for this study. Of 170 patients, 69 (41%) were positive for hepatitis B and/or C virus. These patients were younger, were more frequently male, and had elevated serum α-fetoprotein levels as compared with seronegative intrahepatic cholangiocarcinoma patients. Grossly these tumors were mostly of the mass-forming type, and histologically, cholangiolar differentiation was more frequently seen. We identified N-cadherin as an immunohistochemical marker strongly associated with hepatitis virus infection. The prevalence of viral hepatitis in patients with N-cadherin-positive intrahepatic cholangiocarcinoma was 75%, and that in N-cadherin-negative patients was only 37%. N-cadherin-positive patients were younger, had elevated α-fetoprotein, and had no hepatolithiasis. All N-cadherin-positive intrahepatic cholangiocarcinomas were of the mass-forming type. N-cadherin positivity was strongly associated with cholangiolar morphology and lack of carcinoembryonic antigen and MUC2 expression, whereas K-RAS mutations were less frequent. Our results indicate that a subgroup of intrahepatic cholangiocarcinoma characterized by cholangiolar differentiation and N-cadherin expression is strongly associated with viral hepatitis. ? 2011 USCAP, Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79957884920&doi=10.1038%2fmodpathol.2011.41&partnerID=40&md5=ef6387cc32c4efd8d005cfe1c27c14a1 https://scholars.lib.ntu.edu.tw/handle/123456789/473398 |
ISSN: | 0893-3952 | DOI: | 10.1038/modpathol.2011.41 | SDG/關鍵字: | alpha fetoprotein; carcinoembryonic antigen; K ras protein; mucin 2; nerve cell adhesion molecule; adult; article; bile duct carcinoma; controlled study; female; follow up; gene mutation; hepatitis; Hepatitis B virus; Hepatitis C virus; human; human tissue; immunohistochemistry; liver cell carcinoma; major clinical study; male; prevalence; priority journal; protein expression; sex difference; tissue differentiation; virus hepatitis; alpha-Fetoproteins; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cadherins; Cell Transdifferentiation; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cholangiocarcinoma; Female; Genes, ras; Hepatitis B; Hepatitis C; Hepatitis, Viral, Human; Humans; Male; Middle Aged; Mutation; Tumor Markers, Biological |
顯示於: | 病理學科所 |
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