Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate
Journal
Head and Neck
Journal Volume
27
Journal Issue
12
Pages
1022-1027
Date Issued
2005
Author(s)
Abstract
Background. There is a lack of effective treatment for metastatic adenoid cystic carcinoma (ACC), a usually indolent tumor. We studied the efficacy of imatinib mesylate, a potent inhibitor of KIT tyrosine kinase, in patients with KIT-positive metastatic ACC. Methods. Five patients with lung metastasis were treated in a pilot study with imatinib 400 mg by mouth twice a day. Mutations of c-kit and platelet-derived growth factor receptor (PDGFR)-α in tumors from these patients were analyzed. Results. Disease progression was noted in three of five patients during the short treatment periods, ranging from 2 to 3 weeks. Three patients died of disease within 6 months. No detectable mutations were found in c-kit and PDGFR-α. Conclusion. We observed an unexpected high progression rate of metastatic ACC within short periods during imatinib treatment. Use of imatinib to treat cancers without c-kit or PDGFR-α mutation should be approached with caution. ? 2005 Wiley Periodicals, Inc.
SDGs
Other Subjects
alanine aminotransferase; aspartate aminotransferase; cisplatin; DNA; fluorodeoxyglucose f 18; ifosfamide; imatinib; paclitaxel; platelet derived growth factor receptor; protein tyrosine kinase inhibitor; stem cell factor receptor; adenoid cystic carcinoma; adult; anemia; anorexia; article; bone metastasis; brain metastasis; cancer growth; clinical article; computer assisted tomography; controlled study; diarrhea; dizziness; drug efficacy; drug mechanism; edema; fatigue; female; human; human tissue; liver toxicity; lung metastasis; male; nausea; nuclear magnetic resonance imaging; pilot study; pleura effusion; pleura metastasis; polymerase chain reaction; positron emission tomography; priority journal; rash; thorax radiography; thrombocytopenia; tumor growth; tumor volume; vomiting; Administration, Oral; Adult; Antineoplastic Agents; Carcinoma, Adenoid Cystic; Disease Progression; DNA Mutational Analysis; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Pilot Projects; Piperazines; Pleural Effusion, Malignant; Protein-Tyrosine Kinases; Pyrimidines
Type
journal article