https://scholars.lib.ntu.edu.tw/handle/123456789/473507
Title: | Elastic modulus measurements of human liver and correlation with pathology | Authors: | Yeh, W.-C. Li, P.-C. YUNG-MING JENG Hsu, H.-C. Kuo, P.-L. Li, M.-L. PEI-MING YANG PAI-CHI LI |
Issue Date: | 2002 | Journal Volume: | 28 | Journal Issue: | 4 | Start page/Pages: | 467-474 | Source: | Ultrasound in Medicine and Biology | Abstract: | Viral hepatitis causes fibrosis in the liver and may change mechanical properties of the liver. To evaluate the impact of fibrosis on elastic properties of human liver and to investigate potential benefits of ultrasonic elasticity imaging, 19 fresh human liver samples and 1 hepatic tumor (focal nodular hyperplasia) sample obtained during operations were studied. Simple 1-D estimates based on the cyclic compression-relaxation method were performed. Elastic modulus values were derived from the predetermined strain (controlled by a step motor system) and the stress values (measured by an electronic balance). Each specimen subsequently received histologic examination and a grade of liver fibrosis was scored from 0 to 5. Results show that the elastic modulus values were on the order of several hundreds to thousands of Pascals. The elastic modulus generally increased with the fibrosis grade, although some discrepancies existed at the middle grades of fibrosis (scores 1 to 3). The correlation between the fibrosis score and the elastic modulus was significant (p < 0.01) based on the statistical analysis using the Pearson correlation method. In addition, the relation between the elastic modulus and the fibrosis grade generally exhibited a quadratic trend. It was concluded that severity of fibrosis had a good correlation with stiffness of the liver. Results also indicated that the elasticity imaging of the liver may provide significant clinical values if the elastic modulus can be accurately measured. ? 2002 Elsevier Science Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036283787&doi=10.1016%2fS0301-5629%2802%2900489-1&partnerID=40&md5=04f41bd6c9d4ccca6353b635c26a8080 https://scholars.lib.ntu.edu.tw/handle/123456789/473507 |
ISSN: | 0301-5629 | DOI: | 10.1016/S0301-5629(02)00489-1 | SDG/Keyword: | Biological organs; Elastic moduli; Elasticity; Pathology; Statistical methods; Viral hepatitis; Ultrasonic imaging; adult; article; clinical article; controlled study; correlation analysis; diagnostic accuracy; diagnostic imaging; diagnostic value; disease severity; female; histology; human; human tissue; infant; liver fibrosis; liver tumor; male; priority journal; rigidity; scoring system; statistical analysis; ultrasonic elasticity imaging; young modulus; Elasticity; Female; Humans; Infant; Liver; Liver Cirrhosis; Male; Middle Aged; Ultrasonography |
Appears in Collections: | 病理學科所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.