|Title:||Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation||Authors:||Liu S.-H.
|Issue Date:||2002||Publisher:||American Society for Investigative Pathology Inc.||Journal Volume:||160||Journal Issue:||5||Start page/Pages:||1831-1837||Source:||American Journal of Pathology||Abstract:||
Annexins (ANXs) are a large group of calcium-binding proteins participating in diverse important biological processes. ANXA10 is the least expressed new member of unknown function. We showed that ANXA10 mRNA was expressed in adult liver and hepatocellular carcinoma (HCC), but not in multiple adult and fetal tissues, cholangiocarcinoma, and several other common carcinomas. Of 182 unifocal primary HCCs, ANXA10 mRNA was dramatically reduced in 121 (66%), and the down-regulation correlated with p53 mutation (P = 0.024), early intrahepatic tumor recurrence (P = 0.0007), and lower 4-year survival (P = 0.0014). Down-regulation of ANXA10 was twofold more frequent in large than small HCCs (P = 0.0012), in grade II to III than grade I HCC (P < 0.00001), and in stage IIIA to IV than stage I to II HCC (P < 0.00001). Moreover, ANXA10 down-regulation and p53 mutation acted synergistically toward high-grade (P < 0.00001), high-stage HCC (P < 0.00001), and poorer prognosis (P = 0.0025). Our results indicate that the expression of the tissue- and tumor-restricted ANXA10 is a marker of liver cell differentiation and growth arrest, and its down-regulation associated with malignant phenotype of hepatocytes, vascular invasion, and progression of HCC, leading to poor prognosis. Thus, ANXA10 might serve as a new potential target of gene therapy for HCC.
|ISSN:||0002-9440||DOI:||10.1016/S0002-9440(10)61129-7||SDG/Keyword:||annexin; annexin A10; messenger RNA; mutant protein; protein p53; unclassified drug; adult; article; bile duct carcinoma; cancer grading; cancer growth; cancer invasion; cancer recurrence; cancer size; cancer staging; cancer survival; cell differentiation; controlled study; correlation analysis; down regulation; fetus; gene expression; gene mutation; growth inhibition; histopathology; human; human tissue; liver cell; liver cell carcinoma; major clinical study; phenotype; priority journal; prognosis; protein expression; protein function
|Appears in Collections:||病理學科所|
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