Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Pathology / 病理學科所
  4. Immunohistochemistry of choriocarcinoma: An aid in differential diagnosis and in elucidating pathogenesis
 
  • Details

Immunohistochemistry of choriocarcinoma: An aid in differential diagnosis and in elucidating pathogenesis

Journal
American Journal of Surgical Pathology
Journal Volume
31
Journal Issue
11
Pages
1726-1732
Date Issued
2007
Author(s)
TSUI-LIEN MAO  
Kurman R.J.
Huang C.-C.
Lin M.-C.
Shih I.-M.
DOI
10.1097/PAS.0b013e318058a529
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247892927&doi=10.1097%2fPAS.0b013e318058a529&partnerID=40&md5=4593ee39c73d6aabe602a361af402730
https://scholars.lib.ntu.edu.tw/handle/123456789/473650
Abstract
Choriocarcinoma is traditionally described as being composed of cytotrophoblast and syncytiotrophoblast. Microscopically, these 2 types of cells are intimately associated with each other, forming a characteristic biphasic plexiform pattern, however, the nature of these 2 types of trophoblastic cells is not well understood. In this study, we used immunohistochemistry for several trophoblastic markers to analyze the trophoblastic subpopulations in 36 gestational choriocarcinomas. Eighty-one specimens including placenta, complete mole, placental site nodule, epithelioid trophoblastic tumor, and placental site trophoblastic tumor were analyzed. The antibodies included Mel-CAM, HLA-G, MUC-4, and β-catenin. A semiquantitative assessment of positive cells and the cellular localization of these markers were recorded. We found diffuse strong membranous and cytoplasmic staining for MUC-4 in mononucleate cells in all 36 cases (100%) and a similar pattern of localization in 28 cases (78%) for HLA-G. This distribution was similar to that in normal placentas, where MUC-4 and HLA-G are expressed in the trophoblastic cells of the trophoblastic columns and implantation site. In choriocarcinoma, mononucleate trophoblastic cells showed moderate immunoreactivity for Mel-CAM, a specific marker for implantation site intermediate trophoblast, in 78% of the cases. The MUC-4, HLA-G, and Mel-CAM-positive trophoblastic cells were larger than cytotrophoblastic cells, with more abundant cytoplasm, consistent with the morphology of intermediate trophoblast. In contrast, 31% of the choriocarcinomas contained a very small proportion (<5%) of mononucleate trophoblastic cells compatible with cytotrophoblast that was positive for nuclear β-catenin, a cytotrophoblast-associated marker. These results suggest that choriocarcinoma is composed predominantly of a mixture of syncytiotrophoblast and intermediate trophoblast with only a small proportion of cytotrophoblast. The presence of nuclear β-catenin staining in the cytotrophoblast of choriocarcinoma is consistent with the view that choriocarcinoma develops from transformed cytotrophoblastic cells which are presumably the cancer stem cells that differentiate into either intermediate trophoblast or syncytiotrophoblast. ? 2007 Lippincott Williams & Wilkins, Inc.
Subjects
β-catenin; Choriocarcinoma; HLA-G; Mel-CAM; MUC4
SDGs

[SDGs]SDG3

Other Subjects
beta catenin; CD146 antigen; HLA G antigen; mucin 4; article; cancer stem cell; cell differentiation; cell structure; cell transformation; cellular distribution; choriocarcinoma; clinical article; controlled study; cytoplasm; cytotrophoblast; differential diagnosis; disease marker; epithelioid cell; female; human; human cell; human tissue; hydatidiform mole; immunohistochemistry; immunoreactivity; mononuclear cell; pathogenesis; placenta; syncytiotrophoblast; trophoblast; trophoblastic tumor; Antigens, CD146; beta Catenin; Cell Differentiation; Cell Nucleus; Cell Size; Choriocarcinoma; Diagnosis, Differential; Female; Histocompatibility Antigens Class I; HLA Antigens; Humans; Immunohistochemistry; Maryland; Mucins; Pregnancy; Taiwan; Trophoblastic Tumor, Placental Site; Trophoblasts; Tumor Markers, Biological; Uterine Neoplasms
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science