https://scholars.lib.ntu.edu.tw/handle/123456789/473659
標題: | Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas | 作者: | SUNG-HSIN KUO Chen L.-T. KUN-HUEI YEH MING-SHIANG WU Hsu H.-C. Yeh P.-Y. TSUI-LIEN MAO Chen C.-L. SHIN-LIAN DOONG Lin J.-T. ANN-LII CHENG |
公開日期: | 2004 | 卷: | 22 | 期: | 17 | 起(迄)頁: | 3491-3497 | 來源出版物: | Journal of Clinical Oncology | 摘要: | Purpose: A high percentage of early-stage, high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori dependent. t(11;18)(q21;q21), a genetic aberration highly predictive of H pylori-independent status in low-grade gastric MALT lymphoma, is rarely detected in its high-grade counterpart. This study examined whether nuclear expression of BCL10 or nuclear factor kappa B (NF-κB) is useful in predicting H pylori-independent status in patients with stage IE high-grade gastric MALT lymphomas. Patients and Methods: Twenty-two patients who had participated in a prospective study of H pylori eradication for stage IE high-grade gastric MALT lymphomas were studied. The expression of BCL10 and NF-κB in pretreatment paraffin-embedded lymphoma tissues was evaluated by immunohistochemistry and confocal immunofluorescence microscopy. The presence of t(11;18)(q21;q21) was identified by a multiplex reverse transcriptase polymerase chain reaction of the API2-MALT1 chimeric transcript. Results: Aberrant nuclear expression of BCL10 was detected in seven (87.5%) of eight H pylori-independent and in none of 14 H pylori-dependent high-grade gastric MALT lymphomas (P < .001). All seven patients with nuclear BCL10 expression had nuclear expression of NF-κB, compared with only two of 15 patients without nuclear BCL10 expression (P = .002). As a single variable, the frequency of nuclear expression of NF-κB was also significantly higher in H pylori-independent tumors than in H pylori-dependent tumors (seven of eight [87.5%] v two of 15 [12.3%]; P = .002). The API2-MALT1 fusion transcript was detected in only one (12.5%) of eight H pylori-independent lymphomas. Conclusion: Nuclear expression of BCL10 or NF-κB is highly predictive of H pylori-independent status in high-grade gastric MALT lymphoma, and coexpression of these two markers in the nuclei is frequent. ? 2004 by American Society of Clinical Oncology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-4444333753&doi=10.1200%2fJCO.2004.10.087&partnerID=40&md5=2b60fbd118e553268ec97bbdf62238d7 https://scholars.lib.ntu.edu.tw/handle/123456789/473659 |
ISSN: | 0732-183X | DOI: | 10.1200/JCO.2004.10.087 | SDG/關鍵字: | immunoglobulin enhancer binding protein; protein bcl 10; BCL10 protein, human; biological marker; immunoglobulin enhancer binding protein; signal transducing adaptor protein; tumor protein; article; cancer staging; clinical article; confocal microscopy; controlled study; eradication therapy; fluorescence microscopy; Helicobacter pylori; human; immunohistochemistry; mucosa associated lymphoid tissue lymphoma; priority journal; prospective study; protein expression; reverse transcription polymerase chain reaction; stomach cancer; stomach mucosa; adult; aged; female; gene translocation; male; metabolism; middle aged; mucosa associated lymphoid tissue lymphoma; nonhodgkin lymphoma; virology; Adaptor Proteins, Signal Transducing; Adult; Aged; Biological Markers; Female; Helicobacter pylori; Humans; Immunohistochemistry; Lymphoma, High-Grade; Lymphoma, Mucosa-Associated Lymphoid Tissue; Male; Middle Aged; Neoplasm Proteins; NF-kappa B; Prospective Studies; Translocation, Genetic |
顯示於: | 病理學科所 |
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