Prolonged asymptomatic dense deposit disease in Chinese. Report of 2 cases in Taiwan
Journal
American Journal of Nephrology
Journal Volume
18
Journal Issue
5
Pages
464-468
Date Issued
1998
Author(s)
Abstract
Dense deposit disease (DDD) is a less common form of membranoproliferative glomerulonephritis (MPGN). The disease occurs predominantly in children and young adults and the prognosis is variable. DDD varies considerably in incidence among different populations and has not been reported in Chinese. Herein we reported 2 cases of DDD in young Chinese girls in Taiwan. Although 1 case (case 2) had mild hypertension, both patients had asymptomatic proteinuria and ran a benign course of 8 and 14 years, respectively. The histological features of case 1 resembled membranous glomerulonephritis (MGN) on hematoxylin-eosin stain, but revealed DDD on periodic acid Schiff and chromotrope-2R silver methenamine stains. Whereas case 2 showed focal MPGN on light miscroscopy, she had a fine granular immunofluorescence pattern resembling MGN. Characteristic intramembranous dense deposits were demonstrated by electron microscopy in the basement membranes of the glomeruli, Bowman's capsules and the renal tubules. Both patients were followed closely, and had stable normal renal function 1 year after renal biopsy.
Subjects
Dense deposit disease; Membranoproliferative glomerulonephritis; Membranous glomerulonephritis; Proteinuria
SDGs
Other Subjects
eosin; hematoxylin; methenamine; silver; adult; article; borderline hypertension; case report; chinese; dense deposit disease; disease course; disease duration; electron microscopy; female; follow up; glomerulus basement membrane; histology; human; immunofluorescence; kidney biopsy; kidney function; kidney tubule basement membrane; membranoproliferative glomerulonephritis; microscopy; periodic acid schiff stain; priority journal; prognosis; proteinuria; stain; taiwan; Adult; Female; Glomerulonephritis, Membranoproliferative; Humans; Kidney Glomerulus
Type
journal article