Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer
Journal
Radiation Oncology
Journal Volume
13
Journal Issue
1
Pages
157
Date Issued
2018
Author(s)
Abstract
Background: Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. Methods: The presence of CD3 + , CD4 + , CD8 + , and forkhead box protein P3-positive (FOXP3 + ) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. Results: The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p=0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p=0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p=0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). Conclusions: In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes. ? 2018 The Author(s).
SDGs
Other Subjects
antineoplastic agent; CD3 antigen; CD4 antigen; CD8 antigen; transcription factor FOXP3; CD3 antigen; forkhead transcription factor; FOXP3 protein, human; adult; aged; Article; cancer patient; cancer prognosis; cancer radiotherapy; cancer surgery; cancer survival; cancer tissue; CD3+ tumor infiltrating lymphocyte; CD4+ tumor infiltrating lymphocyte; CD8+ tumor infiltrating lymphocyte; controlled study; diagnostic test accuracy study; distant metastasis free survival; female; forkhead box protein P3 positive tumor infiltrating lymphocyte; human; human cell; human tissue; immunohistochemistry; major clinical study; male; oral surgery; overall survival; recurrence free survival; reference value; survival time; tongue cancer; tumor associated leukocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; chemistry; mortality; pathology; prognosis; Taiwan; tongue tumor; tumor recurrence; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Forkhead Transcription Factors; Humans; Immunohistochemistry; Lymphocytes, Tumor-Infiltrating; Male; Neoplasm Recurrence, Local; Prognosis; Taiwan; Tongue Neoplasms
Publisher
BioMed Central Ltd.
Type
journal article