Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Pathology / 病理學科所
  4. Regular screening of esophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy
 
  • Details

Regular screening of esophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy

Journal
Oral Oncology
Journal Volume
55
Pages
55-60
Date Issued
2016
Author(s)
Huang Y.-C.
YI-CHIA LEE  
PING-HUEI TSENG  
TSENG-CHENG CHEN  
TSUNG-LIN YANG  
PEI-JEN LOU  
JENG-YUH KO  
Liao L.-J.
Hsu W.-L.
YIH-LEONG CHANG  
CHENG-PING WANG  
DOI
10.1016/j.oraloncology.2016.01.008
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960157201&doi=10.1016%2fj.oraloncology.2016.01.008&partnerID=40&md5=90f3585e99a964218e65cf7369152fae
https://scholars.lib.ntu.edu.tw/handle/123456789/473762
Abstract
SummaryObjectives Esophageal squamous cell carcinoma (ESCC) is common in hypopharyngeal squamous cell carcinoma (HSCC) patients. This prospective study is to reveal the prevalence of simultaneous ESCC in newly diagnosed HSCC patients by unsedated transnasal esophagogastroduodenoscopy (EGD) and to analyze the clinical predictors for simultaneous esophageal lesions and their survival. Materials and methods 248 patients with newly diagnosed HSCC and without previous head and neck cancer between 2007 and 2014 were prospectively evaluated for HSCC and simultaneous esophageal lesions by unsedated transnasal EGD. The clinical factors for simultaneous esophageal lesions were evaluated. Survival analysis of the HSCC patients receiving complete treatment was done. Results The mean age was 58 years. 170 HSCC (68.5%) were classified as T3-T4. The procedures were successfully performed (98.4%), except 4 huge tumors. 174 HSCC (85.7%, out of 203 tumors biopsied) were pathologically proved malignancy by this technique. Regarding esophageal lesions (45.5%), ESCC occurred in 36 patients (14.8%), dysplasia without ESCC occurred in 23 (9.4%) and Lugol voiding lesion without ESCC or dysplasia occurred in 52 (21.3%). Alcohol drinking (adjusted OR: 6.95, p < 0.05) and N3 classification (adjusted OR: 2.41, p < 0.05) of HSCC were the independent risk factors for the presence of esophageal lesions. The overall survival of the HSCC patients with ESCC was significantly lower than those without ESCC (p = 0.013). Conclusions Unsedated transnasal EGD is a promising technique for diagnosis of HSCC and simultaneous ESCC. Simultaneous esophageal lesions including ESCC (15%) are common in newly diagnosed HSCC patients, especially with alcohol drinking or N3 disease. ? 2016 Elsevier Ltd.
SDGs

[SDGs]SDG3

Other Subjects
adult; aged; Article; cancer classification; cancer screening; cancer survival; drinking behavior; dysplasia; esophageal squamous cell carcinoma; esophagogastroduodenoscopy; esophagus cancer; female; head and neck cancer; human; hypopharyngeal squamous cell carcinoma; major clinical study; male; overall survival; predictive value; prevalence; priority journal; risk factor; Carcinoma, Squamous Cell; digestive tract endoscopy; Esophageal Neoplasms; Hypopharyngeal Neoplasms; middle aged; procedures; prospective study; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Endoscopy, Digestive System; Esophageal Neoplasms; Female; Humans; Hypopharyngeal Neoplasms; Male; Middle Aged; Prevalence; Prospective Studies; Risk Factors
Publisher
Elsevier Ltd
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science