https://scholars.lib.ntu.edu.tw/handle/123456789/473812
Title: | The determining risk factors for treatment outcomes in patients with squamous cell carcinoma of the hard palate | Authors: | Meng F.-Y. JENG-YUH KO PEI-JEN LOU CHENG-PING WANG TSUNG-LIN YANG Chang C.-H. YIH-LEONG CHANG TSENG-CHENG CHEN |
Issue Date: | 2012 | Journal Volume: | 19 | Journal Issue: | 6 | Start page/Pages: | 2003-2010 | Source: | Annals of Surgical Oncology | Abstract: | Background. The determining risk factors for patients with squamous cell carcinoma of the hard palate are not well verified. Methods. Medical records from our facility of all patients with squamous cell carcinoma of the hard palate receiving curative surgery between March 2003 and May 2009 were reviewed. Results. Seventy-eight patients were enrolled in the study. The 5 year disease-free and overall survival rates were 49.8 and 49.7%, respectively. The 5 year disease-free and overall survival rates were statistically different between positive/close margins and negative margins (24.6% vs. 65.4%, P = 0.02; 20.1% vs. 63.1%, P = 0.001, respectively), with and without soft palate invasion (38.8% vs. 68.9%, P = 0.02; 27.4% vs. 77.5%, P = 0.001, respectively), and soft palate invasion patients with and without perineural invasion (10.4% vs. 52.8%, P = 0.02; 0% vs. 38.1%, P = 0.008, respectively). The rate of positive nodal metastasis for T3 and T4 tumors was 44%. For the tumor with soft palate invasion, the rate of positive nodal metastasis was 29%. After multivariate analyses, soft palate invasion and positive/close margins were the determining risk factors for disease-free and overall survival. Conclusions. Soft palate invasion and positive/close margins were the determining risk factors for disease-free and overall survival in patients with squamous cell carcinoma of the hard palate. Elective neck dissection is suggested for advanced primary tumors (T3 or T4) or tumors with soft palate invasion. ? 2012 Society of Surgical Oncology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865131633&doi=10.1245%2fs10434-011-2214-1&partnerID=40&md5=5cc3148a722095843f5d3a4d30fbbc73 https://scholars.lib.ntu.edu.tw/handle/123456789/473812 |
ISSN: | 1068-9265 | DOI: | 10.1245/s10434-011-2214-1 | SDG/Keyword: | adult; aged; article; cancer invasion; cancer patient; cancer survival; disease free survival; female; human; lymph node metastasis; major clinical study; male; overall survival; palate disease; perineurium; retrospective study; risk factor; soft palate; squamous cell carcinoma; squamous cell carcinoma of the hard palate; treatment outcome; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Palatal Neoplasms; Palate, Hard; Retrospective Studies; Risk Factors; Survival Rate; Treatment Outcome [SDGs]SDG3 |
Appears in Collections: | 病理學科所 |
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