https://scholars.lib.ntu.edu.tw/handle/123456789/473854
標題: | Malignancies of the ear in irradiated patients of nasopharyngeal carcinoma | 作者: | Lo W.-C. Ting L.-L. JENG-YUH KO PEI-JEN LOU TSUNG-LIN YANG YIH-LEONG CHANG CHENG-PING WANG |
公開日期: | 2008 | 卷: | 118 | 期: | 12 | 起(迄)頁: | 2151-2155 | 來源出版物: | Laryngoscope | 摘要: | To report on the clinical profiles and treatment experiences of patients with second primary ear malignancy after treatment of nasopharyngeal carcinoma (NPC). Study Design: Retrospective case series. Methods: A retrospective review of the clinical outcomes and pathology of 11 irradiated NPC patients who subsequently had second primary malignancies of the ear at a single institution. Results: Ten tumors were squamous cell carcinoma and one tumor was chondrosarcoma occurring within the radiation field of previous treatment for NPC. The interval between previous radiotherapy and diagnosis of ear malignancy was 3 to 27 years with a median time of 17 years. Six tumors were located in the external auditory canal, two in the middle ear cavity, two in the periauricular region and one in the mastoid cavity. Four patients underwent surgery, and the other seven patients underwent surgery plus adjuvant radiotherapy. The 3-year disease-free and overall survival rates were 30.3% and 20%, respectively. Conclusions: Postirradiated malignancy of the ear is extremely rare, but is one of the causes of death for NPC long-term survivors despite curative-intended treatment with surgery plus adjuvant radiotherapy is instituted. ? 2008 The American Laryngological, Rhinological and Otological Society, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149355490&doi=10.1097%2fMLG.0b013e3181839b8c&partnerID=40&md5=b70fe7ce49ec4971e2f9e01b1d0e7e34 https://scholars.lib.ntu.edu.tw/handle/123456789/473854 |
ISSN: | 0023-852X | DOI: | 10.1097/MLG.0b013e3181839b8c | SDG/關鍵字: | adult; aged; article; bone necrosis; cancer adjuvant therapy; cancer diagnosis; cancer patient; cancer radiotherapy; cancer staging; cancer surgery; cancer survival; cancer survivor; cause of death; chondrosarcoma; clinical article; disease free survival; ear cancer; epistaxis; external auditory canal; facial nerve paralysis; human; male; mastoid; medical record review; middle ear; nasopharynx; nasopharynx carcinoma; otalgia; otorrhea; overall survival; primary tumor; priority journal; radiation dose; radiation field; radiation injury; retrospective study; squamous cell carcinoma; temporal bone; treatment outcome; tumor localization; wound healing impairment; adjuvant therapy; chondrosarcoma; ear tumor; female; follow up; middle aged; multimodality cancer therapy; nasopharynx tumor; pathology; radiation injury; second cancer; squamous cell carcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Chondrosarcoma; Combined Modality Therapy; Disease-Free Survival; Ear Neoplasms; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Staging; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Radiotherapy Dosage; Radiotherapy, Adjuvant; Retrospective Studies |
顯示於: | 病理學科所 |
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