https://scholars.lib.ntu.edu.tw/handle/123456789/473877
標題: | Significance of extranodal extension of regional lymph nodes in surgically resected non-small cell lung cancer | 作者: | Lee Y.-C. CHEN-TU WU SHUENN-WEN KUO Tseng Y.-T. YIH-LEONG CHANG |
公開日期: | 2007 | 出版社: | American College of Chest Physicians | 卷: | 131 | 期: | 4 | 起(迄)頁: | 993-999 | 來源出版物: | Chest | 摘要: | Study objectives: Regional lymph node (LN) involvement affects the prognosis of patients with surgically resected non-small cell lung cancer (NSCLC). The significance of extranodal extension in these groups of patients was prospectively studied to determine its clinicopathologic relationships and its influence on patient survival. Methods: A total of 199 NSCLC patients who were proved to have regional LN involvement after resection were included. Histologic examinations including tumor cell type, grade of differentiation, vascular invasion, regional LN metastasis emphasizing the number and station of LN involvement, the presence or absence of extranodal extension, and the immunohistochemistry of p53 expression were obtained. The relationships between extranodal extension and histologic type, grade of differentiation, vascular invasion, tumor size, pathologic stage, p53 expression, or patient survival were analyzed. Results: Extranodal extension was significantly higher in women, adenocarcinoma, advanced stage, tumors with vascular invasion, or p53 overexpression. The total number and positive rate of resected LNs with extranodal extension were significantly correlated with advanced stage, tumors with vascular invasion, or p53 overexpression. By multivariate analysis of survival, the presence or total number of LNs with extranodal extension, tumor stage, and p53 expression were significant prognostic factors. The 5-year survival rate of stage IIIA patients without extranodal extension (30.4%) was significantly better than that of stage II patients with extranodal extension (16.8%). No survival difference between extranodal positive stage II and IIIA patients was noted. Conclusions: Extranodal extension of regional LNs is an important prognostic factor in patients with surgically resected NSCLC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247253437&doi=10.1378%2fchest.06-1810&partnerID=40&md5=97063905f74b70a3b9589ba341adb2af https://scholars.lib.ntu.edu.tw/handle/123456789/473877 |
ISSN: | 0012-3692 | DOI: | 10.1378/chest.06-1810 | SDG/關鍵字: | protein p53; adult; aged; article; cancer staging; cancer survival; demography; female; histopathology; human; immunohistochemistry; lung non small cell cancer; lymph node metastasis; major clinical study; male; priority journal; prognosis; prospective study; smoking; statistical analysis; survival rate |
顯示於: | 病理學科所 |
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