https://scholars.lib.ntu.edu.tw/handle/123456789/473899
Title: | The significance of estrogen receptor β in 301 surgically treated non-small cell lung cancers | Authors: | CHEN-TU WU YIH-LEONG CHANG JIN-YUAN SHIH Lee Y.-C. |
Issue Date: | 2005 | Journal Volume: | 130 | Journal Issue: | 4 | Start page/Pages: | 979-986 | Source: | Journal of Thoracic and Cardiovascular Surgery | Abstract: | Objective: Estrogen receptor expression in lung cancer has been understudied, particularly in light of its potential biologic importance in the epidemic of lung cancer in women. The expression of estrogen receptors was investigated to better understand the possible role of sex hormones in lung cancer. Methods: A total of 301 patients with surgically resected non-small cell lung cancers of stages I to III were explored. Sections of paraffin-embedded tumor samples were stained with estrogen receptor α and estrogen receptor β antibodies. Tumors with moderate-to-strong nuclear staining in at least 50% of the tumor cells were scored as positive for overexpression. Results: The overall frequency of overexpression for estrogen receptor β was 45.8% (138/301). It was detected most frequently in female patients (in 54.3% of 127 tumors vs 39.7% of 174 tumors in men, P = .012). However, there was no estrogen receptor α nuclear staining detectable in non-small cell lung cancers. Interestingly, a significant correlation between estrogen receptor β expression, stage of disease, grade of differentiation, smoking status, vascular invasion, and survival in patients with stage II and III disease was found. By using multivariate analysis of survival among patients with stage II and III disease, estrogen receptor β overexpression, stage II tumor, well differentiation, nonsmoking status, and lack of vascular invasion were significantly favorable prognostic factors. Conclusions: The results presented here show for the first time that immunohistochemical expression of estrogen receptor β can be used as a prognostic indicator in patients with surgically resected stage II and III non-small cell lung cancers. These observations might offer a possibility for hormonal therapy in patients with lung cancer. Copyright ? 2005 by The American Association for Thoracic Surgery. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-26444533390&doi=10.1016%2fj.jtcvs.2005.06.012&partnerID=40&md5=36191ebbfb6acc0f548f2484f02178d1 https://scholars.lib.ntu.edu.tw/handle/123456789/473899 |
ISSN: | 0022-5223 | DOI: | 10.1016/j.jtcvs.2005.06.012 | SDG/Keyword: | estrogen receptor alpha; estrogen receptor beta; paraffin; sex hormone; adult; article; cancer staging; cancer surgery; cancer survival; controlled study; correlation analysis; female; hormone determination; human; lung non small cell cancer; major clinical study; male; multivariate analysis; priority journal; prognosis; sex role; smoking; staining; statistical significance; tumor cell; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Estrogen Receptor beta; Female; Humans; Lung Neoplasms; Male; Middle Aged |
Appears in Collections: | 病理學科所 |
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