Giant cell arteritis with CD8+ instead of CD4+ T lymphocytes as the predominant infiltrating cells in a young woman
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
37
Journal Issue
4
Pages
246-249
Date Issued
2004
Author(s)
Abstract
Giant cell arteritis is rarely reported in people aged less than 50 years. We report a case of giant cell arteritis in a woman who developed symptoms of dizziness, headache, bilateral sensorineural hearing impairment, and had 1 episode of transient left hemiparesis before the age of 30. Carotid angiography showed multiple segmental narrowing in cranial vessels. Subsequently, at the age of 31, she had weight loss and developed a fever. Chest radiograph revealed mediastinal widening, and chest computed tomography revealed dilated pulmonary arteries and veins. Coronary angiography and aortography showed irregular narrowing of the descending aorta and multiple stenosis, with aneurysmal dilatation involving the proximal and distal coronary, pulmonary and mesenteric arteries. Multinucleated giant cells and predominant CD8+ T lymphocyte infiltration were noted in a left temporal artery biopsy specimen. The patient's age and the finding of dilated pulmonary veins and prominent CD8+ T lymphocytes in the biopsy specimen suggest that this case was a distinct form of systemic giant cell arteritis.
Subjects
Aneurysm; CD8+ T-lymphocytes; Giant cell arteritis; Pulmonary veins; Sensorineural hearing loss; Takayasu's arteritis
SDGs
Other Subjects
CD4 antigen; CD8 antigen; adult; angiocardiography; aorta stenosis; aortography; artery dilatation; article; blood vessel biopsy; carotid arteriography; case report; computer assisted tomography; coronary artery aneurysm; descending aorta; dizziness; female; fever; giant cell; giant cell arteritis; headache; hemiparesis; histopathology; human; human tissue; lymphocytic infiltration; mesenteric artery; perception deafness; pulmonary artery aneurysm; pulmonary artery disease; symptom; T lymphocyte; temporal artery; thorax radiography; vein dilatation; weight reduction; Adult; Carotid Arteries; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cerebrovascular Accident; Female; Headache; Hearing Loss; Humans; Temporal Arteries; Temporal Arteritis; Tinnitus
Type
journal article