https://scholars.lib.ntu.edu.tw/handle/123456789/473951
標題: | Pulmonary pleomorphic (spindle) cell carcinoma: Peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma | 作者: | YIH-LEONG CHANG Lee Y.-C. JIN-YUAN SHIH CHEN-TU WU |
公開日期: | 2001 | 出版社: | Elsevier Ireland Ltd | 卷: | 34 | 期: | 1 | 起(迄)頁: | 91-97 | 來源出版物: | Lung Cancer | 摘要: | Pleomorphic (spindle) cell carcinoma, also known as monophasic sarcomatoid carcinoma, is a rare primary pulmonary malignancy. This type of tumor shows concurrent presence of malignant epithelial and homologous sarcomatoid spindle cell components by coexpressing cytokeratin and vimentin in various degrees. Sixteen cases (four central endobronchial lesions and 12 peripheral parenchymal masses) were studied clinicopathologically. Men were affected far more frequently than women (13:3). The patients were between 56 and 80 years of age. The disease is strongly associated with smoking. Among seven of the patients who underwent surgical resection, four of them had mediastinum, pleura and chest wall invasions, and three of them had regional lymph node metastases. All of the patients succumbed to early distant metastases (range 2 weeks-5 months) in organs including brain, bone, adrenal gland, and unusual sites such as esophagus, jejunum, rectum and kidney. The remaining nine inoperable cases were late stage disease and treated with chemoradiotherapy with little effect. The median duration of survival was 3 months. All parenchymal masses appeared as cavities with marked central necrosis, and only peripheral rim of tumor cells was left. More definite diagnostic results will depend on further tissue sections and can be confirmed by immunohistochemical studies. Significantly fewer Ki-67, p53 and c-erb B-2 oncoprotein expressions were also noted. ? 2001 Elsevier Science Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034853936&doi=10.1016%2fS0169-5002%2801%2900224-0&partnerID=40&md5=bd6b91332900063c81be9dc24bb3f1a1 https://scholars.lib.ntu.edu.tw/handle/123456789/473951 |
ISSN: | 0169-5002 | DOI: | 10.1016/S0169-5002(01)00224-0 | SDG/關鍵字: | antiinfective agent; Ki 67 antigen; oncoprotein; protein p53; adult; aged; body regions; cancer chemotherapy; cancer staging; clinical article; clinical feature; conference paper; controlled study; data analysis; differential diagnosis; disease association; female; human; human tissue; lung non small cell cancer; lymph node metastasis; male; mediastinum metastasis; necrosis; pleura metastasis; priority journal; protein expression; sex difference; smoking habit; spindle cell carcinoma; survival rate |
顯示於: | 病理學科所 |
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