Blood compatibility of fluorodiol-containing polyurethanes
Journal
Journal of Polymer Science, Part A: Polymer Chemistry
Journal Volume
45
Journal Issue
15
Pages
3231-3242
Date Issued
2007
Author(s)
Abstract
Abstract A number of fluorodiol‐containing polyurethanes were synthesized from the fluorodiols 1 H ,1 H ,12 H ,12 H ‐perfluoro‐1,12‐dodecanediol (PFDDOL) and 2,2,3,3,‐tetrafluoro‐1,4‐butanediol (TF) and characterized using Fourier transform infrared spectroscopy, gel permeation chromatography, and electron spectroscopy for chemical analysis (ESCA). The effect of the fluorine content on the physical and surface properties of the polymers and on their blood compatibility was investigated. A higher content of fluorine atoms exposed on the surface results in a lower surface energy, a lower relative index of platelet adhesion, and a lower fibrinogen/albumin adsorption ratio (F/A ratio). The polyurethane containing a 50% molar ratio of PFDDOL and TF as the chain extender exhibited the lowest surface energy and superior blood compatibility (RIPA value, 0.06; F/A ratio, 0.672). © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 3231–3242, 2007
SDGs
Type
journal article