https://scholars.lib.ntu.edu.tw/handle/123456789/474380
標題: | Left atrial spontaneous echo contrast in asymptomatic patients with a mechanical valve prothesis | 作者: | Lee, Tsung-Ming NAI-KUAN CHOU Su, Sheng-Fang Lin, Yueh-Juh MING-FONG CHEN Liau, Chiau-Suong Lee, Yuan-Teh Chu, Shu-Hsun |
公開日期: | 1996 | 卷: | 62 | 期: | 6 | 起(迄)頁: | 1790-1795 | 來源出版物: | Annals of Thoracic Surgery | 摘要: | Background. Valve thromboembolism may be a fatal complication of mechanical valve prosthesis if detected late. Spontaneous echo contrast (SEC) is a well-documented prothrombotic phenomenon; here we report it in asymptomatic patients with a mechanical valve prosthesis. Methods. Ninety-two asymptomatic patients with a mechanical valve prosthesis for underlying rheumatic heart disease underwent transesophageal echocardiography. Appendage area, peak filling and emptying velocities of the left atrial appendage, and the presence or absence of SEC and thrombi were determined. The results of 56 patients without SEC or thrombi (group I) were compared with those of 24 patients with SEC and no thrombi (group II) and 12 patients with thrombi (group III). Results. Spontaneous echo contrast was present in 39% of the asymptomatic patients with a mechanical valve prosthesis. Although 12 patients had cardiac thrombi, including valve thrombi in 4, no patients presented symptoms. Anticoagulant therapy had no significant association with SEC and atrial thrombi. There was a significantly greater prevalence of atrial fibrillation and mitral prosthesis in groups II and III than in group I. Two patterns of left atrial appendage flow were identified: one was organized biphasic flow with peak filling velocities of 41.2 ± 17.2 cm/s and emptying velocities of 40.5 ± 17.5 cm/s. The other showed irregular, very low peak filling velocities (10.4 ± 11.5 cm/s) and emptying velocities (12.3 ± 13.1 cm/s). The former flow pattern was associated with sinus rhythm and the latter form was associated with atrial fibrillation. Conclusions. There was a relatively high prevalence of SEC and thrombi in patients with a mechanical valve prosthesis. Patients with a valve prosthesis may not have clinical symptoms. Anticoagulation intensity was not associated with the occurrence of SEC and thrombi. Patients with a mitral valve prosthesis and atrial fibrillation were identified as a high-risk of subgroup for the development of SEC and thrombi. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030540972&doi=10.1016%2fS0003-4975%2896%2900739-4&partnerID=40&md5=daffd4264ea6216ec91369658f8c5e5e https://scholars.lib.ntu.edu.tw/handle/123456789/474380 |
ISSN: | 0003-4975 | DOI: | 10.1016/S0003-4975(96)00739-4 | SDG/關鍵字: | anticoagulant agent; adult; aged; article; controlled study; echocardiography; female; heart valve prosthesis; human; major clinical study; male; priority journal; rheumatic heart disease; thromboembolism; Adult; Aged; Echocardiography, Transesophageal; Female; Heart Atria; Heart Diseases; Heart Valve Prosthesis; Humans; Male; Middle Aged; Thrombosis |
顯示於: | 醫學系 |
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