https://scholars.lib.ntu.edu.tw/handle/123456789/474475
標題: | Association of cadherin23 single nucleotide polymorphism with age-related hearing impairment in Han Chinese | 作者: | Hwang J.-H. Liu K.S. Wu C.-C. TIEN-CHEN LIU |
關鍵字: | age-related hearing impairment; cadherin23; Han Chinese; humans; single nucleotide polymorphism | 公開日期: | 2012 | 卷: | 147 | 期: | 3 | 起(迄)頁: | 531-534 | 來源出版物: | Otolaryngology - Head and Neck Surgery (United States) | 摘要: | Objective. Genetic variation of cadheri23 (cdh23; 753G>A in exon 7) has been implicated with age-related hearing impairment (ARHI) in mice. This study aimed to test the association of the CDH23 tag single nucleotide polymorphism (SNP) in intron 7 with ARHI in Han Chinese. Study Design. Individual cohort study. Setting. Tertiary medical center. Subjects and Methods. A total of 1175 Han Chinese subjects were divided into the case group (n = 310, 26% with poorest hearing) and the control group (n = 308, the 26% with best hearing) according to the Zhigh score converted from the original frequency-specific hearing thresholds. The CDH23 SNP locus (rs7087735: C/T) in intron 7 (coordinate: 72996763) shown in the HapMap was genotyped with correlation to the hearing phenotype. Results. The genotype distributions of CDH23 (CC/CT/TT) were not significantly different between the case and control group (P = .489). Compared with genotype CC, the odds ratios of the genotypes CT and TT for ARHI were not significantly different after adjustment for other environmental factors (P = .299 for CT; P = .610 for TT). Conclusions. Despite that the Ahl allele of Cdh23 had been implicated with ARHI in mice, we found no positive association of the CDH23 tag SNP in intron 7 with ARHI in Han Chinese. ? 2012 American Academy of Otolaryngology-Head and Neck Surgery Foundation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870432571&doi=10.1177%2f0194599812446904&partnerID=40&md5=4182900f455945a98aae7e00f2ab6dec https://scholars.lib.ntu.edu.tw/handle/123456789/474475 |
ISSN: | 0194-5998 | DOI: | 10.1177/0194599812446904 | SDG/關鍵字: | cadherin 23; adult; article; auditory threshold; Chinese; cohort analysis; controlled study; environmental factor; female; gene locus; genetic risk; genetic variability; genotype; haplotype map; hearing impairment; human; human tissue; intron; major clinical study; male; single nucleotide polymorphism; tertiary health care; Adult; Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group; Cadherins; Cohort Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Introns; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Presbycusis; Taiwan |
顯示於: | 醫學系 |
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