https://scholars.lib.ntu.edu.tw/handle/123456789/474482
標題: | The grainyhead-like 2 gene (GRHL2) single nucleotide polymorphism is not associated with age-related hearing impairment in Han Chinese | 作者: | Lin Y.-H. CHEN-CHI WU Hsu C.-J. Hwang J.-H. TIEN-CHEN LIU |
公開日期: | 2011 | 卷: | 121 | 期: | 6 | 起(迄)頁: | 1303-1307 | 來源出版物: | Laryngoscope | 摘要: | Objectives/Hypothesis: The grainyhead-like 2 gene (GRHL2) was found to be associated with age-related hearing impairment (ARHI) in Europeans. We tested whether the same association exists in the Han Chinese population. Study Design: Individual cohort study. Methods: Among a total of 1,175 Han Chinese volunteers, 310 were classified into the case group (the 26% with poorest hearing), and 308 were placed into the control group (the 26% with best hearing) according to the Zhigh scores converted from the original frequency-specific hearing thresholds. The GRHL2 single nucleotide polymorphism locus (rs10955255: A/G) in intron 1 (coordinate: 102605581) shown in the HapMap was genotyped with correlation to the audiologic phenotypes. Results: The genotype distributions of GRHL2 (AA/AG/GG) were not significantly different between the control and the case groups (P = .349). Compared to genotype AA, the odds ratios of the GRHL2 genotypes AG and GG for ARHI were not significantly different after adjustment for other environmental risk factors by logistic regression analyses; 0.78 6 0.139, 95% confidence interval (CI) = 0.55 ? 1.10, P = .160 for AG; 0.85 ± 0.283, 95% CI = 0.44 ? 1.63, P = .625 for GG. In each audiogram pattern, AA was most common, but the adjusted odds ratios of the genotypes AG and GG for ARHI still were not significantly different. Conclusions: Our results showed no positive association between GRHL2 polymorphisms and ARHI in Han Chinese individuals. Population differences might be a key factor leading to nonreplication of the association. ? 2011 The American Laryngological, Rhinological and Otological Society, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79958273686&doi=10.1002%2flary.21771&partnerID=40&md5=e004d8873d0a33c8d0e65436c05ffdf3 https://scholars.lib.ntu.edu.tw/handle/123456789/474482 |
ISSN: | 0023-852X | DOI: | 10.1002/lary.21771 | SDG/關鍵字: | grainyhead like 2 protein; protein; unclassified drug; adult; aged; aging; alcohol consumption; article; audiography; case control study; Chinese; chronic kidney disease; cohort analysis; controlled study; diabetes mellitus; environmental factor; female; gene locus; genetic association; genotype; haplotype map; hearing impairment; human; hyperlipidemia; hypertension; intron; ischemic heart disease; kidney disease; major clinical study; male; obesity; phenotype; priority journal; risk factor; scoring system; single nucleotide polymorphism; smoking; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Comorbidity; Coronary Artery Disease; DNA-Binding Proteins; Female; Genotype; Humans; Logistic Models; Male; Middle Aged; Obesity, Abdominal; Odds Ratio; Polymorphism, Single Nucleotide; Presbycusis; Renal Insufficiency, Chronic; Transcription Factors |
顯示於: | 醫學系 |
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