https://scholars.lib.ntu.edu.tw/handle/123456789/474491
標題: | Diffusion tensor imaging of the subcortical auditory tract in subjects with congenital cochlear nerve deficiency | 作者: | Wu C.-M. Ng S.-H. Wang J.-J. TIEN-CHEN LIU |
公開日期: | 2009 | 卷: | 30 | 期: | 9 | 起(迄)頁: | 1773-1777 | 來源出版物: | American Journal of Neuroradiology | 摘要: | BACKGROUND AND PURPOSE: Cochlear nerve deficiency (CND), including aplasia and hypoplasia, is a rare cause of congenital hearing loss. The purpose of this study was to evaluate the neuronal integrity of the subcortical auditory pathway in subjects with CND by diffusion tensor MR imaging (DTI). MATERIALS AND METHODS: Twelve subjects with unilateral congenital CND were included in this prospective study. Twelve normal-hearing subjects served as controls. DTIs were acquired from these subjects on a 3T MR imaging scanner. Several indices including axial diffusivity (λ∥), radial diffusivity (λ⊥), mean diffusivity (MD), and fractional anisotropy (FA) along the auditory pathway were extracted. Two regions of interest were selected bilaterally for evaluation: the lateral lemniscus (LL) and inferior colliculus (IC). The mean values of λ∥, λ⊥, MD, and FA at both regions of interest were compared between the ipsilateral and contralateral sides of subjects with CND with those in the control group. RESULTS: Significant decrease of FA and increase of MD on both the ipsilateral and contralateral sides of patients with CND as compared with normal subjects in both LL and IC were found. The decrease of FA was due to the increase of λ⊥, whereas λ∥ remained unchanged. CONCLUSIONS: The maintained axial diffusion implied that the orientation of neural fibers along the subcortical auditory pathway in subjects with unilateral CND is intact. However, the reduction in FA and increase in λ⊥ on both the ipsilateral and contralateral sides might be attributed to axonal loss and/or demyelination of the subcortical auditory tract in these subjects. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349894961&doi=10.3174%2fajnr.A1681&partnerID=40&md5=019d574f794f5793093447301c2a1fc8 https://scholars.lib.ntu.edu.tw/handle/123456789/474491 |
ISSN: | 0195-6108 | DOI: | 10.3174/ajnr.A1681 | SDG/關鍵字: | adolescent; adult; anisotropy; aplasia; article; child; clinical article; cochlear nerve; congenital deafness; diffusion tensor imaging; female; human; hypoplasia; inferior colliculus; male; nerve malformation; Adolescent; Adult; Auditory Pathways; Child; Diffusion Tensor Imaging; Female; Hearing Loss, Sensorineural; Humans; Male; Vestibulocochlear Nerve Diseases; Young Adult |
顯示於: | 醫學系 |
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