Transient elastography correlated with diffusion-weighted magnetic resonance imaging and cholestatic complications
Journal
Journal of the Formosan Medical Association
Journal Volume
118
Journal Issue
11
Pages
1522-1527
Date Issued
2019
Author(s)
Abstract
Background/Purpose: The study aim to investigate the correlation between diffusion-weighted magnetic resonance imaging (DW-MRI) and transient elastography (TE) liver fibrosis findings in children with cholestatic liver diseases, and the utility of TE findings to predict cholestatic complications in children. Methods: This cross-sectional study enrolled 36 cholestatic children (21 boys and 15 girls). All study subjects underwent TE and DW-MRI studies to assess liver stiffness. All study subjects were followed prospectively, and their cholestatic complications were analyzed. The optimum cut-off TE value for the prediction of cholestatic complications was determined by receiver operating characteristic (ROC) analysis. Results: A significant negative correlation between liver stiffness measurements (LSMs) and right-liver-to-psoas apparent diffusion coefficient ratios (LTPARs) was found in the study cohort (correlation coefficient = ?0.52, p = 0.001). An LSM cut-off > 8.6 kPa was optimal for predicting complications of cholestasis in 6 months of this cohort (p < 0.001). Survival analysis revealed that an LSM of >8.6 kPa was significantly predictive of cholestatic complications in 6 months (hazard ratio = 4.89; 95% CI = 1.41–16.97; p = 0.01). Conclusion: TE and DW-MRI findings showed a similar ability to predict liver fibrosis in cholestatic children. The LSMs measured by TE are predictive of the occurrence of cholestatic complications in 6 months in children with cholestatic liver diseases. ? 2018 Formosan Medical Association
SDGs
Other Subjects
Alagille syndrome; apparent diffusion coefficient; Article; bile duct atresia; blood clotting disorder; child; cholangitis; cholestasis; clinical article; cohort analysis; common bile duct cyst; correlation coefficient; cross-sectional study; diagnostic accuracy; diagnostic test accuracy study; diffusion weighted imaging; female; gastrointestinal hemorrhage; human; inborn error of metabolism; intrahepatic cholestasis; liver fibrosis; liver stiffness; liver transplantation; male; newborn hepatitis; Niemann Pick disease; predictive value; primary sclerosing cholangitis; prospective study; sensitivity and specificity; survival analysis; transient elastography; cholestasis; comparative study; complication; diagnostic imaging; diffusion weighted imaging; elastography; infant; liver; liver cirrhosis; pathology; preschool child; receiver operating characteristic; reproducibility; Child, Preschool; Cholestasis; Cross-Sectional Studies; Diffusion Magnetic Resonance Imaging; Elasticity Imaging Techniques; Female; Humans; Infant; Liver; Liver Cirrhosis; Male; Predictive Value of Tests; Reproducibility of Results; ROC Curve
Publisher
Elsevier B.V.
Type
journal article