https://scholars.lib.ntu.edu.tw/handle/123456789/475186
標題: | Ursodeoxycholic acid (UDCA) therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis | 作者: | CHIEN-YI CHEN PO-NIEN TSAO HUEY-LING CHEN HUNG-CHIEH CHOU Hsieh W.-S. MEI-HWEI CHANG |
公開日期: | 2004 | 卷: | 145 | 期: | 3 | 起(迄)頁: | 317-321 | 來源出版物: | Journal of Pediatrics | 摘要: | Objective To determine the effect of ursodeoxycholic acid (UDCA) in very-low-birth-weight (VLBW) infants with parenteral nutrition-associated cholestasis (PNAC). Study design A retrospective study of all VLBW infants with PNAC who were admitted to a tertiary referral center was conducted. Patients were classified as treatment group (receiving UDCA within 14 days after onset of cholestasis) or control group (no medical treatment). Patients who received abdominal surgery were excluded. Results A total of 30 patients were recruited, including 12 in the treatment group and 18 in the control group. The demographic data, total fasting duration, onset of cholestasis, age to tolerance of full feeds, and the duration of parenteral nutrition (PN) before the onset of cholestasis were comparable between the two groups. There was a trend in the control group to later onset of cholestasis. The patients who received UDCA therapy with doses of 10 to 30 mg/kg/day had a shorter duration of cholestasis than the control group (62.8 vs 92.4 days, P=.006). Furthermore, the peak serum levels of direct bilirubin also was significantly lower in the treatment group. Conclusion UDCA can improve the course of PNAC in VLBW infants. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-4444256601&doi=10.1016%2fj.jpeds.2004.05.038&partnerID=40&md5=d6e030305445cc26a14aac3f1b40881e https://scholars.lib.ntu.edu.tw/handle/123456789/475186 |
ISSN: | 0022-3476 | DOI: | 10.1016/j.jpeds.2004.05.038 | SDG/關鍵字: | bilirubin; ursodeoxycholic acid; abdominal surgery; article; bilirubin blood level; cholestasis; clinical article; controlled study; demography; diarrhea; diet restriction; disease duration; drug effect; feeding; female; health center; hospital admission; human; infant; liver failure; male; nutritional tolerance; onset age; parenteral nutrition; patient referral; priority journal; very low birth weight; Bilirubin; Birth Weight; Case-Control Studies; Cholestasis; Female; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Male; Parenteral Nutrition; Retrospective Studies; Treatment Outcome; Ursodeoxycholic Acid |
顯示於: | 醫學教育暨生醫倫理學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。