https://scholars.lib.ntu.edu.tw/handle/123456789/475217
Title: | Prenatal exposure to PM 2.5 and Congenital Heart Diseases in Taiwan | Authors: | CHING-CHUN HUANG Chen B.-Y. Pan S.-C. YI-LWUN HO Yue Leon Guo |
Issue Date: | 2019 | Publisher: | Elsevier B.V. | Journal Volume: | 655 | Start page/Pages: | 880-886 | Source: | Science of the Total Environment | Abstract: | Gestational exposure to ambient air pollution has been associated with Congenital Heart Diseases (CHDs). However, only a few studies, with inconsistent results, have investigated the effects of PM 2.5 exposure during early pregnancy. This study aims to evaluate the association between prenatal exposure to PM 2.5 and CHDs occurrence. We selected 782 births reported to have CHDs between 2007 and 2014 from the Taiwanese Birth Registry and randomly selected 4692 controls without any birth defects using a population-based case-control design. Data of exposure to ambient air pollutants, mainly PM 2.5 , PM 10 , CO, SO 2 , NO 2 , and O 3 during weeks 3–8 of pregnancy were retrieved from air quality monitoring stations and interpolated to every township using ordinary kriging. We applied unconditional logistic regression models adjusted for potential confounders to evaluate the associations. The results revealed a positive correlation between increased PM 2.5 exposure (adjusted odds ratio [aOR] = 1.21, 95% confidence interval [CI] = 1.03–1.42, per interquartile range change = 13.4 μg/m 3 ) during early pregnancy and overall CHDs occurrence. Furthermore, we found that atrial septal defect (aOR = 1.43, 95% CI = 1.01–2.02), endocardial cushion defect (aOR = 2.37, 95% CI = 1.01–5.58), and pulmonary artery and valve stenosis (aOR = 1.71, 95% CI = 1.06–2.78) were significantly associated with PM 2.5 exposures. No similar effects were observed for the other air pollutants. This study has demonstrated some positive associations between increased PM 2.5 exposure during the critical period of cardiac embryogenesis and certain CHDs occurrence. © 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057012655&doi=10.1016%2fj.scitotenv.2018.11.284&partnerID=40&md5=a55c4e2b368c34fc9d0a01355293e2db https://scholars.lib.ntu.edu.tw/handle/123456789/475217 |
ISSN: | 0048-9697 | DOI: | 10.1016/j.scitotenv.2018.11.284 | SDG/Keyword: | Air pollution; Air quality; Cardiology; Heart; Interpolation; Obstetrics; Regression analysis; Congenital heart disease; Kriging; PM2.5; Pregnancy; Prenatal exposure; Diseases; carbon monoxide; nitrogen dioxide; ozone; sulfur dioxide; air quality; atmospheric pollution; cardiovascular disease; kriging; particulate matter; pollution exposure; pregnancy; air pollutant; air pollution; air quality; ambient air; Article; cardiovascular risk; case control study; child; congenital heart disease; congenital malformation; controlled study; disease association; embryo development; endocardial cushion defect; environmental exposure; female; first trimester pregnancy; heart atrium septum defect; heart development; human; kriging; major clinical study; male; newborn; particulate matter; population based case control study; prenatal exposure; priority journal; pulmonary artery stenosis; pulmonary valve stenosis; Taiwan; chemically induced; environmental monitoring; heart disease; infant; particulate matter; pregnancy; prenatal exposure; preschool child; prevalence; Taiwan; Air Pollutants; Case-Control Studies; Child; Child, Preschool; Environmental Exposure; Environmental Monitoring; Female; Heart Diseases; Humans; Infant; Infant, Newborn; Male; Particulate Matter; Pregnancy; Prenatal Exposure Delayed Effects; Prevalence; Taiwan |
Appears in Collections: | 環境職業醫學科 |
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