https://scholars.lib.ntu.edu.tw/handle/123456789/475234
標題: | Current asthma in schoolchildren is related to fungal spores in classrooms | 作者: | CHI-HSIEN CHEN Chao H.J. CHANG-CHUAN CHAN Chen B.-Y. Yue Leon Guo |
公開日期: | 2014 | 出版社: | American College of Chest Physicians | 卷: | 146 | 期: | 1 | 起(迄)頁: | 123-134 | 來源出版物: | Chest | 摘要: | BACKGROUND: The presence of visible mold in households is associated with asthma. However, the role of "classroom fungus" in the development of childhood asthma, as well as the fungal species that may lead to asthma, remains controversial. This nationwide school survey was conducted to investigate the correlation between fungal spores in classrooms and asthma in schoolchildren. M ETHODS: From April to May 2011, a cross-sectional survey was conducted to assess allergic/asthmatic conditions in schoolchildren aged 6 to 15 years old in 44 schools across Taiwan. Personal histories and current asthmatic conditions were collected using a modified International Study of Asthma and Allergies in Childhood questionnaire. Fungal spores in classroom were collected using a Burkard Personal Air Sampler and counted under light microscopy. Three-level hierarchical modeling was used to determine the complex correlation between fungal spores in classrooms and childhood asthma. R ESULTS: The survey was completed by 6,346 out of 7,154 parents (88.7%). The prevalences of physician-diagnosed asthma, current asthma, and asthma with symptoms reduced on holidays or weekends (ASROH) were 11.7%, 7.5%, and 3.1%, respectively. The geometric mean spore concentrations of total fungi, Aspergillus/Penicillium , and basidiospores were 2,181, 49, and 318 spores/m3 . Aspergillus/Penicillium and basidiospores were significantly correlated with current asthma and ASROH aft er adjusting for personal and school factors. Of those with current asthma, 41% reported relief of symptoms during weekends. CONCLUSIONS: Classroom Aspergillus/Penicillium and basidiospores are significantly associated with childhood asthma and ASROH. Government health policy should explore environmental interventions for the elimination of fungal spores in classrooms to reduce the prevalence of childhood asthma. ? 2014 AMERICAN COLLEGE OF CHEST PHYSICIANS. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903825901&doi=10.1378%2fchest.13-2129&partnerID=40&md5=d4c5203dc30a084124af9af0cef98d2e https://scholars.lib.ntu.edu.tw/handle/123456789/475234 |
ISSN: | 0012-3692 | DOI: | 10.1378/chest.13-2129 | SDG/關鍵字: | adolescent; air sampler; allergy; Aspergillus; asthma; basidiospore; child; classroom; conference paper; cross-sectional study; disease association; female; fungus spore; health care policy; human; international study of asthma and allergies in childhood questionnaire; major clinical study; male; medical history; microscopy; named inventories, questionnaires and rating scales; parent; Penicillium; prevalence; priority journal; school; school child; statistical model; Taiwan; Adolescent; Air Pollution, Indoor; Asthma; Child; Cross-Sectional Studies; Female; Humans; Hypersensitivity, Immediate; Incidence; Male; Questionnaires; Retrospective Studies; Schools; Spores, Fungal; Taiwan |
顯示於: | 環境職業醫學科 |
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