https://scholars.lib.ntu.edu.tw/handle/123456789/475246
標題: | Mortality from liver cancer and leukaemia among polyvinyl chloride workers in Taiwan: An updated study | 作者: | Hsieh H.-I. PAU-CHUNG CHEN Wong R.-H. CHUNG-LI DU Chang Y.-Y. Wang J.-D. TSUN-JEN CHENG |
公開日期: | 2011 | 卷: | 68 | 期: | 2 | 起(迄)頁: | 120-125 | 來源出版物: | Occupational and Environmental Medicine | 摘要: | Objectives: To investigate types of cancer caused by occupational exposure to vinyl chloride monomer (VCM) and the temporal mortality trends of these cancers in workers from polyvinyl chloride (PVC) manufacturing factories in Taiwan, with follow-up of the cohort extended by 15 years, from 1980 to 2007. Methods: A retrospective cohort study of workers from six PVC factories in Taiwan was conducted. 3336 male PVC workers were enrolled and further linked with the National Mortality Registry and National Household Registry databases. Standardised mortality ratios (SMR) with 95% CIs were calculated and compared to the general Taiwanese male population. Cause-specific mortality between two study periods, 1980-1997 and 1998-2007, was compared. Six-year moving averages of the SMRs were calculated to examine mortality trends. Results: Liver cancer mortality increased during 1989-1994 (SMR 1.90, 95% CI 1.01 to 3.25), reached a peak during 1991-1996 (SMR 2.31, 95% CI 1.39 to 3.61) and became non-significant during 1994-1999 (SMR 1.42, 95% CI 0.80 to 2.34). Leukaemia mortality significantly increased during 1984-1989 (SMR 6.06, 95% CI 1.24 to 17.53), reached a peak during 1985-1990 (SMR 7.56, 95% CI 2.06 to 19.35) and became non-significant during 1991-1996 (SMR 3.24, 95% CI 0.39 to 11.69). The mortality trend for haemolymphopoietic cancer showed a similar pattern to that of leukaemia. Conclusions: VCM may increase the risk of liver cancer and leukaemia. When VCM exposure was controlled at worksites, mortality from these cancers returned to background levels. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78751683045&doi=10.1136%2foem.2010.056978&partnerID=40&md5=61f9efa5604903fd991d524117a3724d https://scholars.lib.ntu.edu.tw/handle/123456789/475246 |
ISSN: | 1351-0711 | DOI: | 10.1136/oem.2010.056978 | SDG/關鍵字: | polyvinylchloride; adult; article; cancer mortality; cause of death; follow up; human; industrial worker; leukemia; liver cancer; male; occupational exposure; priority journal; Taiwan; Adult; Epidemiologic Methods; Humans; Leukemia; Liver Neoplasms; Lymphoma; Male; Middle Aged; Mortality; Occupational Diseases; Occupational Exposure; Polyvinyl Chloride; Taiwan; Young Adult |
顯示於: | 環境職業醫學科 |
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