https://scholars.lib.ntu.edu.tw/handle/123456789/475290
Title: | Pathogens and outcomes in pediatric septic shock patients supported by extracorporeal membrane oxygenation | Authors: | Chang T.-H. EN-TING WU CHUN-YI LU SHU-CHIEN HUANG Yang T.-I. CHING-CHIA WANG JONG-MIN CHEN PING-ING LEE LI-MIN HUANG LUAN-YIN CHANG |
Issue Date: | 2018 | Publisher: | Elsevier Ltd | Journal Volume: | 51 | Journal Issue: | 3 | Start page/Pages: | 385-391 | Source: | Journal of Microbiology, Immunology and Infection | Abstract: | Background: Refractory septic shock is the leading cause of mortality in children. There is limited evidence to support extracorporeal membrane oxygenation (ECMO) use in pediatric septic shock. We described the etiology and outcomes of septic patients in our institution and attempted to find predictive factors. Methods: We retrospectively reviewed 55 pediatric patients with septic shock who required ECMO support in a tertiary medical center from 2008 to 2015. Septic shock was defined as culture proved or clinical suspected sepsis with hypotension or end-organ hypoperfusion. ECMO would be applied when pediatric advanced life support steps were performed thoroughly without clinical response. Patient's demographics, laboratory parameters before and after ECMO, and outcomes were analyzed. Results: Among 55 children with ECMO support, 31% of them survived on discharge. For 25 immunocompromised patients, causal pathogens were found in 17 patients: 7 due to bacteremia, 9 with preexisting virus infections and one with invasive fungal infection. Among 30 previously healthy patients, causal pathogens were found in 18 patients: 10 due to bacteremia (the most common was pneumococcus), 7 with preexisting virus infections including influenza (n = 4), adenovirus (n = 2), RSV, and 1 patient had mixed virus and bacterial infections. Predictive factors associated with death were arterial blood gas pH, CO2 and Glasgow Coma Scale (p < 0.05). SOFA score was a valuable predictive scoring system for outcome prediction (p < 0.05). Conclusions: Pediatric patients with refractory septic shock had high mortality rate and ECMO could be used as a rescue modality, and SOFA score could be applied to predict outcomes. ? 2017 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027413251&doi=10.1016%2fj.jmii.2017.07.012&partnerID=40&md5=da8107fb5f41a4c89a8bcf263b6791aa https://scholars.lib.ntu.edu.tw/handle/123456789/475290 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2017.07.012 | SDG/Keyword: | adenovirus infection; adolescent; adult; arterial carbon dioxide tension; arterial pH; Article; bacteremia; child; childhood mortality; clinical outcome; extracorporeal oxygenation; female; Glasgow coma scale; hospital discharge; human; immunocompromised patient; infant; influenza; major clinical study; male; mixed infection; newborn; pediatric advanced life support; respiratory syncytial virus infection; retrospective study; septic shock; Sequential Organ Failure Assessment Score; Streptococcus pneumoniae; survival rate; systemic mycosis; virus infection; Adenoviridae; bacterial infection; blood analysis; blood gas analysis; complication; extracorporeal oxygenation; microbiology; mortality; multivariate analysis; pathogenicity; pH; preschool child; procedures; prognosis; septic shock; statistical model; treatment outcome; Adenoviridae; Adolescent; Bacteremia; Bacterial Infections; Blood Chemical Analysis; Blood Gas Analysis; Child; Child, Preschool; Extracorporeal Membrane Oxygenation; Glasgow Coma Scale; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Influenza, Human; Logistic Models; Multivariate Analysis; Patient Discharge; Prognosis; Retrospective Studies; Shock, Septic; Streptococcus pneumoniae; Survival Rate; Treatment Outcome |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.