Plasma uric acid and the risk of type 2 diabetes in a Chinese community
Journal
Clinical Chemistry
Journal Volume
54
Journal Issue
2
Pages
310-316
Date Issued
2008
Author(s)
Abstract
BACKGROUND: Previous cross-sectional studies have shown hyperuricemia to be prevalent among individuals with metabolic syndrome, but the evidence from prospective studies of an association between uric acid and diabetes risk is limited. We prospectively investigated the association between plasma concentrations of uric acid and the incidence of type 2 diabetes in Chinese individuals. METHODS: We conducted a community-based prospective cohort study of 2690 participants (age range, 35-97 years) in the Chin-Shan Community Cardiovascular Cohort Study, who were found to be free of diabetes and cardiovascular disease during baseline assessment at study entry in 1990. During a median 9.0-year follow-up, 548 participants developed type 2 diabetes. RESULTS: High plasma uric acid concentrations were associated with a higher prevalence of metabolic syndrome. After adjustment for age, sex, body mass index, and other covariates, the relative risks (RR) of diabetes according to uric acid quintile were 1.11, 1.29, 1.40, and 1.63 [95% confidence interval (CI), 1.20 -2.23; P for trend <0.001]. After additional adjustment for metabolic syndrome, the RR for comparing the participants in the fifth and first uric acid quintiles was 1.40 (95% CI, 1.02-1.92; P for trend = 0.027). In joint analyses, participants who were in the highest uric acid quintile and also had metabolic syndrome had a 3.3-fold greater risk of diabetes (95% CI, 2.27- 4.94) than those in the lowest uric acid quintile and without metabolic syndrome. CONCLUSIONS: These findings suggest a modest positive association between plasma uric acid concentration and the incidence of type 2 diabetes in Chinese individuals. The association between hyperuricemia and diabetes was partly mediated through the metabolic syndrome. ? 2007 American Association for Clinical Chemistry.
SDGs
Other Subjects
uric acid; adult; aged; article; body mass; cardiovascular disease; Chinese; cohort analysis; community care; confidence interval; controlled study; demography; female; follow up; human; incidence; major clinical study; male; metabolic syndrome X; non insulin dependent diabetes mellitus; prevalence; prospective study; risk factor; uric acid blood level; Adult; Aged; Asian Continental Ancestry Group; Biological Markers; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Risk Factors; Taiwan; Uric Acid
Type
journal article