Sibling and parental history in type 2 diabetes risk among ethnic Chinese: The Chin-Shan Community Cardiovascular Cohort Study
Journal
European Journal of Preventive Cardiology
Journal Volume
15
Journal Issue
6
Pages
657-662
Date Issued
2008
Author(s)
Hsu, Hsiu-Ching
Chen, Pei-Chun
Lee, Yuan-Teh
Abstract
This study aims to compare various family history profiles as predictors of diabetes in a community-based prospective cohort because few prospective studies have examined the association of family history with diabetes risk in ethnic Chinese populations. Among 2960 participants free from baseline diabetes through the Chin-Shan Community Cardiovascular Cohort Study, there were 548 cases that developed diabetes after a median 9 years of follow-up. After multivariate adjustment, sibling history was associated with diabetes [Relative risk (RR): 2.08, 95% confidence interval (CI): 1.42?€“3.06, P = 0.0002]. Both maternal and paternal histories had similar effects (RR: 1.62, 95% CI: 1.04?€“2.51 for paternal history, RR: 1.36, 95% CI: 0.98?€“1.89 for maternal history). Obese participants with sibling history increased the risk of diabetes by 4.6-fold (RR: 4.61, 95% CI: 2.93?€“7.26), compared with those with neither obesity nor family history. The findings support the hypothesis that sibling history is more important than parental history for diabetes risk. ? 2008, European Society of Cardiology. All rights reserved.
SDGs
Other Subjects
adult; article; cardiovascular risk; Chinese; controlled study; disease association; ethnic group; family history; female; follow up; history; human; insulin dependent diabetes mellitus; major clinical study; male; multivariate analysis; obesity; priority journal; prospective study; sibling; age; aged; Asian; China; cohort analysis; comparative study; ethnology; genetic predisposition; genetics; incidence; middle aged; non insulin dependent diabetes mellitus; obesity; parent; pedigree; proportional hazards model; risk assessment; risk factor; Adult; Age Factors; Aged; Asian Continental Ancestry Group; China; Cohort Studies; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Humans; Incidence; Male; Middle Aged; Obesity; Parents; Pedigree; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Siblings
Type
journal article