Cushings disease in children: Report of three cases
Journal
Pediatrics and Neonatology
Journal Volume
51
Journal Issue
5
Pages
303-307
Date Issued
2010
Author(s)
Abstract
Cushings disease is rare in children and adolescents. We report the clinical presentations of three children with Cushings disease. All three exhibited the typical symptoms and signs of weight gain and growth retardation. Tw o also demonstrated personality changes, hypertension and hypokalemia, the last of these being rarely reported in patients with Cushings disease. Lack of diurnal changes in serum cortisol levels was the most common biochemical finding. Serum cortisol levels were suppressed by low-dose dexamethasone in one patient, which is not typical for patients with Cushings disease. Imaging studies are essential for localizing the tumor. Transsphenoidal surgery remains the treatment of choice, and pituitary irradiation should be considered for those patients whose tumors cannot be totally removed. Careful follow-up of these patients with awareness of the possibilities of relapse and the complications of hypopituitarism is indicated. ? 2010 Taiwan Pediatric Association.
SDGs
Other Subjects
cortisone acetate; dexamethasone; growth hormone; hydrocortisone; levothyroxine sodium; testosterone cipionate; hydrocortisone; ACTH secreting adenoma; article; case report; child; Cushing disease; diabetes insipidus; drug megadose; female; follow up; growth retardation; human; hydrocortisone blood level; hypertension; hypokalemia; hypopituitarism; low drug dose; male; personality disorder; school child; weight gain; blood; Cushing disease; Child; Female; Humans; Hydrocortisone; Male; Pituitary ACTH Hypersecretion
Type
journal article