https://scholars.lib.ntu.edu.tw/handle/123456789/476154
標題: | The potential of tetrandrine as a protective agent for ischemic stroke | 作者: | Chen Y. Tsai Y.-H. SHENG-HONG TSENG |
關鍵字: | Alkaloid; Ischemic stroke; Tetrandrine | 公開日期: | 2011 | 卷: | 16 | 期: | 9 | 起(迄)頁: | 8020-8032 | 來源出版物: | Molecules | 摘要: | Stroke is one of the leading causes of mortality, with a high incidence of severe morbidity in survivors. The treatment to minimize tissue injury after stroke is still unsatisfactory and it is mandatory to develop effective treatment strategies for stroke. The pathophysiology of ischemic stroke is complex and involves many processes including energy failure, loss of ion homeostasis, increased intracellular calcium level, platelet aggregation, production of reactive oxygen species, disruption of blood brain barrier, and inflammation and leukocyte infiltration, etc. Tetrandrine, a bisbenzylisoquinoline alkaloid, has many pharmacologic effects including anti-inflammatory and cytoprotective effects. In addition, tetrandrine has been found to protect the liver, heart, small bowel and brain from ischemia/reperfusion injury. It is a calcium channel blocker, and can inhibit lipid peroxidation, reduce generation of reactive oxygen species, suppress the production of cytokines and inflammatory mediators, inhibit neutrophil recruitment and platelet aggregation, which are all devastating factors during ischemia/reperfusion injury of the brain. Because tetrandrine can counteract these important pathophysiological processes of ischemic stroke, it has the potential to be a protective agent for ischemic stroke. ? 2011 by The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053273291&doi=10.3390%2fmolecules16098020&partnerID=40&md5=7a277b20f0bb3f32cbfbe2dcb2d77a74 https://scholars.lib.ntu.edu.tw/handle/123456789/476154 |
ISSN: | 1420-3049 | DOI: | 10.3390/molecules16098020 | SDG/關鍵字: | antiinflammatory agent; antioxidant; antithrombocytic agent; benzylisoquinoline derivative; calcium channel blocking agent; tetrandrine; animal; brain infarction; brain ischemia; chemistry; human; pathophysiology; reperfusion injury; review; Animals; Anti-Inflammatory Agents; Antioxidants; Benzylisoquinolines; Brain Infarction; Brain Ischemia; Calcium Channel Blockers; Humans; Platelet Aggregation Inhibitors; Reperfusion Injury |
顯示於: | 醫學系 |
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