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  4. RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-Deficit in Sustained Attention and Executive Function
 
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RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-Deficit in Sustained Attention and Executive Function

Journal
Biological Psychiatry
Journal Volume
64
Journal Volume
64
Journal Issue
9
Journal Issue
9
Pages
789-796
Start Page
789
End Page
796
ISSN
0006-3223
Date Issued
2008-11-01
Author(s)
Liu Y.-L.
Fann C.S.-J.
CHIH-MIN LIU  orcid-logo
WEI J. CHEN  
Wu J.-Y.
Hung S.-I.
Chen C.-H.
Jou Y.-S.
Liu S.-K.
TZUNG-JENG HWANG  orcid-logo
MING-HSIEN HSIEH  
Chang C.C.
Yang W.-C.
Lin J.-J.
Chou F.H.-C.
Faraone S.V.
Tsuang M.T.
Hwu H.-G.
DOI
10.1016/j.biopsych.2008.04.035
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/476433
Abstract
Background: In a previous linkage study of schizophrenia that included Taiwanese samples, the marker D22S278 (22q12.3) was significantly linked to schizophrenia (p = .001). Methods: We conducted fine mapping of the implicated genomic region, with 47 validated single nucleotide polymorphism (SNP) markers around 1 Mb of D22S278, in a Taiwanese sample of 218 pedigrees with at least 2 siblings affected with schizophrenia. We examined the association of these SNPs and their haplotypes with schizophrenia and with subgroups defined by the presence and absence of deficits in sustained attention as assessed by undegraded and degraded continuous performance tests (CPTs). We also examined subgroups defined by deficits in categories achieved in the Wisconsin Card Sort Test (WCST). Results: Three of five candidate vulnerability genes (RASD2, APOL5, MYH9, EIF3S7, and CACNG2), which had marginally significant associations with schizophrenia, had significant associations with schizophrenic patients who did not have deficits in sustained attention on the undegraded CPT (RASD2 gene SNP rs736212; p = .0008 with single locus analysis) and the degraded CPT (MYH9 gene haplotype 1-1-1-1 of SNP rs3752463 - rs1557540 - rs713839 - rs739097; p = .0059 with haplotype analysis). We also found a significant association for patients who showed no deficits in executive function as measured by categories achieved in the WCST (CACNG2 gene haplotype 2-1-1-1 of SNP rs2267360 - rs140526 - rs1883987 - rs916269; p = .0163 with haplotype analysis). Conclusions: The genes RASD2, MYH9, and CACNG2 might be vulnerability genes for neuropsychologically defined subgroups of schizophrenic patients. ? 2008 Society of Biological Psychiatry.
SDGs

[SDGs]SDG3

Other Subjects
adult; article; cacng2 gene; chromosome 22q; controlled study; diagnostic and statistical manual of mental disorders; female; gene; gene frequency; gene function; gene locus; genetic association; haplotype; human; major clinical study; male; MYH9 gene; priority journal; rasd2 gene; schizophrenia; single nucleotide polymorphism; Adult; Aged; Attention; Calcium Channels; Chromosomes, Human, Pair 22; Family Health; Female; Genetic Predisposition to Disease; GTP-Binding Proteins; Humans; Male; Middle Aged; Molecular Motor Proteins; Myosin Heavy Chains; Neuropsychological Tests; Polymorphism, Single Nucleotide; Problem Solving; Schizophrenia
Type
journal article

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