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  4. Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway
 
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Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway

Journal
Cancer
Journal Volume
118
Journal Issue
23
Pages
5757-5767
Date Issued
2012
Author(s)
TSU-YAO CHENG  
MING-SHIANG WU  
Lin J.-T.
MING-TSAN LIN  
CHIA-TUNG SHUN  
Huang H.-Y.
KUO-TAI HUA  
Kuo M.-L.
DOI
10.1002/cncr.27565
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84869506420&doi=10.1002%2fcncr.27565&partnerID=40&md5=c683bd1ee77f3c087037520f9b04ed97
https://scholars.lib.ntu.edu.tw/handle/123456789/477443
Abstract
BACKGROUND: Annexin A1 (AnxA1) has been well-known as a glucocorticoid-regulated anti-inflammatory protein, and it is implicated in tumorigenesis in a tumor type-specific pattern. However, the role of AnxA1 in gastric cancer (GC) is indeterminate, and the underlying mechanism is not clear. The purpose of this study was to evaluate the prognostic significance and associated mechanism of AnxA1 in GC. METHODS: Immunohistochemical staining was employed to analyze 118 GC patients. Both AnxA1 gain-of-function and loss-of-function approaches were performed in GC cells. Western blotting and reverse-transcription polymerase chain reaction were used for assessment of the AnxA1 regulation mechanism in GC cells. An intraperitoneal inoculation model in severe combined immunodeficient mice was used for an in vivo assay. RESULTS: High AnxA1 expression was significantly associated with peritoneal metastasis (P =.009) and serosal invasion (P =.044). Cox multivariate analysis showed that high AnxA1 expression was an independent risk factor for poor overall survival in GC patients (P =.037). AnxA1 expression positively correlated with invasiveness of human GC cells both in vitro and in vivo. AnxA1 could regulate the GC cell invasion through the formyl peptide receptor (FPR)/extracellular signal-regulated kinase/integrin beta-1-binding protein pathway, and all 3 FPRs (FPR1 through FPR3) were involved in the regulation process. CONCLUSIONS: High AnxA1 expression was associated with more serosal invasion, more peritoneal metastasis, and poorer overall survival in GC patients. The current study demonstrated a novel mechanism involving FPRs, extracellular signal-regulated kinases 1 and 2, and integrin beta-1-binding protein 1 by which AnxA1 regulated GC cell invasion. ? 2012 American Cancer Society.
SDGs

[SDGs]SDG3

Other Subjects
binding protein; formylpeptide receptor; integrin beta 1 binding protein 1; lipocortin 1; mitogen activated protein kinase; unclassified drug; adult; animal experiment; animal model; article; cancer cell; cancer invasion; cancer prognosis; cancer survival; cell migration; controlled study; disease association; female; gain of function mutation; human; human cell; human tissue; immunohistochemistry; in vitro study; in vivo study; loss of function mutation; major clinical study; male; mouse; nonhuman; overall survival; peritoneum metastasis; priority journal; protein expression; signal transduction; stomach cancer; stomach carcinogenesis; upregulation; Western blotting; Adult; Aged; Animals; Annexin A1; Extracellular Signal-Regulated MAP Kinases; Female; HEK293 Cells; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred NOD; Middle Aged; Neoplasm Invasiveness; Phosphorylation; Receptors, Formyl Peptide; Stomach Neoplasms
Type
journal article

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