https://scholars.lib.ntu.edu.tw/handle/123456789/477487
標題: | Effects of immune-modulating formula on lymphocyte distribution and leukocyte adhesion molecule expression in ICU patients | 作者: | Lai S.-J. MING-TSAN LIN ANNE CHAO Yen S.-L. |
關鍵字: | ICU patients; Immune-modulating formula; Leukocyte adhesion molecule; Lymphocyte distribution | 公開日期: | 2007 | 卷: | 32 | 期: | 1 | 起(迄)頁: | 1-8 | 來源出版物: | Nutritional Sciences Journal | 摘要: | This study compared the effects of immune-modulating and general balanced formulas on lymphocyte distribution and leukocyte adhesion molecule expression in intensive care unit (ICU) patients. Twelve patients with Acute Physiology and Chronic Health Evaluation (APACHE) II score 8-15 were allocated to 2 groups. Control group received general balanced formula whereas test group received either one of the immune-modulating formula (Impact-glutamine or Nu-Immune). The immune-modulating formulas contain arginine inverted commas ω-3 fatty acid and glutamine in addition to complete balanced nutrition. Blood samples were collected before and 3 and 7 d after enteral feeding in all patients, and were analyzed for lymphocyte distribution and leukocyte adhesion molecule expression by flow cytometry. The results showed that after enteral feeding for 3 days, the CD8 percentage was higher and CD4/CD8 ratio was lower in the test group than those of the control group. There were no differences in CD3, CD4, CD8, CD19 distribution and leukocyte CD11a/CD18, CD11b/CD18 expression before and after enteral feeding in both groups. Also, no differences in these parameters were observed between the 2 groups. Since CD3 is the marker of T cells and CD19 is the marker of B cells, and CD11a/CD18, CD11b/CD18 expression are correlated with inflammatory reaction, these results suggest that immuno-modulating formulas do not result in immunosuppression. Compared with the balanced formula, immuno-modulating formula had no favorable effect on lymphocyte distribution and leukocyte associated inflammation in ICU patients. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247860666&partnerID=40&md5=740c63de06c5c7dd6eb9394a997294ef https://scholars.lib.ntu.edu.tw/handle/123456789/477487 |
ISSN: | 1011-6958 | SDG/關鍵字: | arginine; glutamine; L selectin; omega 3 fatty acid; adult; antigen expression; article; blood sampling; CD4 CD8 ratio; cellular distribution; controlled study; enteric feeding; female; flow cytometry; human; human experiment; immunomodulation; intensive care unit; leukocyte adherence; lymphocyte; lymphocyte subpopulation; male; scoring system |
顯示於: | 醫學系 |
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