https://scholars.lib.ntu.edu.tw/handle/123456789/477534
標題: | Tumor necrosis factor-α and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma | 作者: | MING-SHIANG WU Huang S.-P. YU-TING CHANG CHIA-TUNG SHUN MING-CHU CHANG MING-TSAN LIN HSIU-PO WANG Lin J.-T. |
公開日期: | 2002 | 卷: | 185 | 期: | 1 | 起(迄)頁: | 106-109 | 來源出版物: | Journal of Infectious Diseases | 摘要: | To investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to Epstein-Barr virus (EBV) infection, 30 patients with EBV-positive gastric carcinoma (GC), 120 patients with EBV-negative GC, and 220 control subjects were enrolled. Promoter polymorphisms of tumor necrosis factor (TNF)-α at positions -238 and -308 and of interleukin (IL)-10 at position -1082 were determined. The frequency of the high-producer allele (-308A) in the TNF-α gene was significantly higher among EBV-positive GC patients compared with control subjects (23.3% vs. 12.0%, P < .05), whereas the frequency of the high-producer allele (-1082G) in the IL-10 gene was significantly higher among EBV-negative GC patients compared with control subjects (6.3% vs. 3.0%, P < .05). These data support the notion that genetic factors may modify the outcomes of infectious diseases through different TNF-α- or IL-10-producing capabilities. ? 2002 Infectious Diseases Society of America. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036137221&doi=10.1086%2f324771&partnerID=40&md5=8616fbccfd5d341dc4e0ca49d4f33dbf https://scholars.lib.ntu.edu.tw/handle/123456789/477534 |
ISSN: | 0022-1899 | DOI: | 10.1086/324771 | SDG/關鍵字: | interleukin 10; tumor necrosis factor alpha; article; controlled study; disease association; disease course; DNA polymorphism; Epstein Barr virus; gene locus; human; infection sensitivity; major clinical study; pathogenesis; priority journal; stomach carcinoma; virus infection; Adenocarcinoma; China; Epstein-Barr Virus Infections; Gene Frequency; Humans; Interleukin-10; Polymorphism, Genetic; Promoter Regions (Genetics); Stomach Neoplasms; Taiwan; Tumor Necrosis Factor-alpha |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。