Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection
Journal
Inflammation Research
Journal Volume
45
Journal Issue
3
Pages
109-112
Date Issued
1996
Author(s)
Abstract
To examine the effects of three nitric oxide synthase inhibitors on survival in a murine sepsis model. Prospective randomized experimental trials. Laboratory. Female Balb/c mice. Escherichia coli (10(8) colony-forming-units/body) were injected into the peritoneal cavities of Balb/c mice. NG-nitro-L-arginine-methyl-ester, NG-monomethyl-L-arginine, or N-iminoethyl-L-ornithine was given at various concentrations, intraperitoneally, one hour before bacterial challenge. One hundred and fifteen animals were observed for survival. These inhibitors provided the mice no protection from the bacterial challenge. Notably, pretreatment with NG-nitro-L-arginine-methyl-ester (100 mg/kg i.p.) actually reduced survival time after E. coli challenge. Inhibition of nitric oxide production improved neither the survival time nor rate in this murine sepsis model.
Type
journal article