https://scholars.lib.ntu.edu.tw/handle/123456789/477684
標題: | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis | 作者: | Escala-Garcia M. Abraham J. Andrulis I.L. Anton-Culver H. Arndt V. Ashworth A. Auer P.L. Auvinen P. Beckmann M.W. Beesley J. Behrens S. Benitez J. Bermisheva M. Blomqvist C. Blot W. Bogdanova N.V. Bojesen S.E. Bolla M.K. B?rresen-Dale A.-L. Brauch H. Brenner H. Brucker S.Y. Burwinkel B. Caldas C. Canzian F. Chang-Claude J. Chanock S.J. Chin S.-F. Clarke C.L. Couch F.J. Cox A. Cross S.S. Czene K. Daly M.B. Dennis J. Devilee P. Dunn J.A. Dunning A.M. Dwek M. Earl H.M. Eccles D.M. Eliassen A.H. Ellberg C. Evans D.G. Fasching P.A. Figueroa J. Flyger H. Gago-Dominguez M. Gapstur S.M. Garc?a-Closas M. Garc?a-S?enz J.A. Gaudet M.M. George A. Giles G.G. Goldgar D.E. Gonz?lez-Neira A. Grip M. Gu?nel P. Guo Q. Haiman C.A. H?kansson N. Hamann U. Harrington P.A. Hiller L. Hooning M.J. Hopper J.L. Howell A. CHIUN-SHENG HUANG Huang G. Hunter D.J. Jakubowska A. John E.M. Kaaks R. Kapoor P.M. Keeman R. Kitahara C.M. Koppert L.B. Kraft P. Kristensen V.N. Lambrechts D. Le Marchand L. Lejbkowicz F. Lindblom A. Lubi?ski J. Mannermaa A. Manoochehri M. Manoukian S. Margolin S. Martinez M.E. Maurer T. Mavroudis D. Meindl A. Milne R.L. Mulligan A.M. Neuhausen S.L. Nevanlinna H. Newman W.G. Olshan A.F. Olson J.E. Olsson H. Orr N. Peterlongo P. Petridis C. Prentice R.L. Presneau N. Punie K. Ramachandran D. Rennert G. Romero A. Sachchithananthan M. Saloustros E. Sawyer E.J. Schmutzler R.K. Schwentner L. Scott C. Simard J. Sohn C. Southey M.C. Swerdlow A.J. Tamimi R.M. Tapper W.J. Teixeira M.R. Terry M.B. Thorne H. Tollenaar R.A.E.M. Tomlinson I. Troester M.A. Truong T. Turnbull C. Vachon C.M. van der Kolk L.E. Wang Q. Winqvist R. Wolk A. Yang X.R. Ziogas A. Pharoah P.D.P. Hall P. Wessels L.F.A. Chenevix-Trench G. Bader G.D. D?rk T. Easton D.F. Canisius S. Schmidt M.K. |
公開日期: | 2020 | 出版社: | Nature Research | 卷: | 11 | 期: | 1 | 起(迄)頁: | 312 | 來源出版物: | Nature Communications | 摘要: | Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis. ? 2020, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077940819&doi=10.1038%2fs41467-019-14100-6&partnerID=40&md5=6ef84dca5c17763d57ef018ed22f0366 https://scholars.lib.ntu.edu.tw/handle/123456789/477684 |
ISSN: | 2041-1723 | DOI: | 10.1038/s41467-019-14100-6 | SDG/關鍵字: | cancer; data set; enzyme; enzyme activity; gene; heritability; network analysis; survival; angiogenesis; apoptosis; Article; breast cancer; cancer prognosis; cancer specific survival; cancer survival; cell cycle regulation; circadian rhythm; estrogen receptor negative breast cancer; estrogen receptor positive breast cancer; female; gene frequency; gene linkage disequilibrium; genetic association; genetic variability; genome-wide association study; genotype; germline mutation; germline related prognostic module; human; major clinical study; prognostic assessment; single nucleotide polymorphism; biology; breast tumor; gene regulatory network; genetic variation; genetics; genome-wide association study; germ cell; prognosis; signal transduction; estrogen receptor; G protein alpha 16; GNA11 protein, human; guanine nucleotide binding protein alpha subunit; Apoptosis; Breast Neoplasms; Circadian Clocks; Computational Biology; Female; Gene Regulatory Networks; Genetic Variation; Genome-Wide Association Study; Genotype; Germ Cells; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Prognosis; Receptors, Estrogen; Signal Transduction |
顯示於: | 醫學系 |
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