https://scholars.lib.ntu.edu.tw/handle/123456789/477737
標題: | Current Status of the Management of Hereditary Breast and Ovarian Cancer in Asia: First Report by the Asian BRCA Consortium | 作者: | Nakamura S. Kwong A. Kim S.-W. Iau P. Patmasiriwat P. Dofitas R. Aryandono T. Hu Z. CHIUN-SHENG HUANG Ginsburg O. Rashid M.U. Sarin R. Teo S.-H. |
公開日期: | 2016 | 出版社: | S. Karger AG | 卷: | 19 | 期: | 1 | 起(迄)頁: | 53-60 | 來源出版物: | Public Health Genomics | 摘要: | Background: BRCA1/BRCA2 mutations are associated with an increased lifetime risk for hereditary breast and ovarian cancer (HBOC). Compared with the Western developed countries, genetic testing and risk assessment for HBOC in Asia are less available, thus prohibiting the appropriate surveillance, clinical strategies and cancer management. Methods: The current status of HBOC management in 14 Asian countries, including genetic counselling/testing uptakes and clinical management options, was reviewed. We analysed how economic factors, healthcare and legal frameworks, and cultural issues affect the genetic service availability in Asia. Results: In 2012, only an estimated 4,000 breast cancer cases from 14 Asian countries have benefited from genetic services. Genetic testing costs and the absence of their adoption into national healthcare systems are the main economic barriers for approaching genetic services. Training programmes, regional accredited laboratories and healthcare professionals are not readily available in most of the studied countries. A lack of legal frameworks against genetic discrimination and a lack of public awareness of cancer risk assessment also provide challenges to HBOC management in Asia. Conclusions: The Asian BRCA Consortium reports the current disparities in genetic services for HBOC in Asia and urges the policy makers, healthcare sectors and researchers to address the limitations in HBOC management. ? 2015 S. Karger AG. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955206573&doi=10.1159%2f000441714&partnerID=40&md5=8ccd3a3bdf5e1321714124729fcf16ea https://scholars.lib.ntu.edu.tw/handle/123456789/477737 |
ISSN: | 1662-4246 | DOI: | 10.1159/000441714 | SDG/關鍵字: | Article; Asia; breast cancer; familial cancer; female; first degree relative; genetic counseling; genetic screening; genetic service; health care system; health insurance; Hong Kong; human; income; Japan; major clinical study; Malaysia; ovary cancer; Pakistan; Philippines; priority journal; risk management; Singapore; social welfare; South Korea; Taiwan; Thailand; Viet Nam; adult; Asia; Asian continental ancestry group; cultural factor; disease management; economics; genetics; health care delivery; hereditary breast and ovarian cancer syndrome; needs assessment; procedures; risk assessment; statistics and numerical data; BRCA1 protein; BRCA2 protein; Adult; Asia; Asian Continental Ancestry Group; BRCA1 Protein; BRCA2 Protein; Cross-Cultural Comparison; Disease Management; Female; Genetic Counseling; Genetic Testing; Health Services Accessibility; Hereditary Breast and Ovarian Cancer Syndrome; Humans; Needs Assessment; Risk Assessment |
顯示於: | 醫學系 |
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