|Title:||Evaluation of the treatment response to neoadjuvant chemotherapy in locally advanced breast cancer using combined magnetic resonance vascular maps and apparent diffusion coefficient||Authors:||Wu L.-A.
|Issue Date:||2015||Publisher:||John Wiley and Sons Inc.||Journal Volume:||42||Journal Issue:||5||Start page/Pages:||1407-1420||Source:||Journal of Magnetic Resonance Imaging||Abstract:||
Purpose To evaluate the treatment response of locally advanced breast cancer (LABC) to neoadjuvant chemotherapy using magnetic resonance (MR) vascular maps and apparent diffusion coefficient (ADC) at 3T. Materials and Methods Thirty-one patients with LABC who underwent breast MR studies before, after the first course, and after completing neoadjuvant chemotherapy were enrolled. Vascular morphology was retrieved via Hessian matrix and the voxels of the vessels and volume of vessels were measured automatically. Whole tumor mean ADC values were calculated. Clinical responders were defined as >50% tumor reduction in the final MR studies. Pathologically complete responders were also recorded. Results There were 21 clinical responders and 10 nonresponders. Compared to the nonresponders after the first course, the responders were characterized by more vascular reduction of the breast lesion and decreased bilateral vascular discrepancy (voxels and volume), and increments in the ADC value and ADC percentage of the lesions (all P < 0.05). There were three pathological complete responders who showed more apparent early vascular reduction of the lesion breast (voxels and volume) and increments in the ADC value than others (P=0.02, 0.01 and 0.02, respectively). Conclusion The early changes of MR vascular maps and ADC are associated with the final treatment response of LABC. ? 2015 Wiley Periodicals, Inc.
|ISSN:||1053-1807||DOI:||10.1002/jmri.24915||SDG/Keyword:||cisplatin; cyclophosphamide; docetaxel; epirubicin; fluorouracil; folinic acid; navelbine; trastuzumab; contrast medium; gadobutrol; organometallic compound; adult; apparent diffusion coefficient; Article; breast cancer; cancer adjuvant therapy; cancer morphology; cancer staging; clinical article; contrast enhancement; controlled study; diffusion coefficient; drug response; female; human; locally advanced breast cancer; mastectomy; middle aged; nuclear magnetic resonance imaging; priority journal; receiver operating characteristic; retrospective study; sensitivity and specificity; tumor vascularization; tumor volume; voxel based morphometry; adjuvant chemotherapy; breast; Breast Neoplasms; image enhancement; neoadjuvant therapy; nuclear magnetic resonance imaging; pathology; procedures; treatment outcome; Adult; Breast; Breast Neoplasms; Chemotherapy, Adjuvant; Contrast Media; Female; Humans; Image Enhancement; Magnetic Resonance Imaging; Middle Aged; Neoadjuvant Therapy; Organometallic Compounds; Retrospective Studies; Treatment Outcome
|Appears in Collections:||醫學系|
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