https://scholars.lib.ntu.edu.tw/handle/123456789/477754
標題: | Habitual sleep-wake behaviors and lifestyle as predictors of diurnal cortisol patterns in young breast cancer survivors: A longitudinal study | 作者: | FEI-HSIU HSIAO WEN-HUNG KUO Jow G.-M. KING-JEN CHANG Yang P.-S. Lam H.-B. Lee J.-J. CHIUN-SHENG HUANG Liu Y.-F. Lai Y.-M. |
公開日期: | 2015 | 出版社: | Elsevier Ltd | 卷: | 53 | 起(迄)頁: | 60-68 | 來源出版物: | Psychoneuroendocrinology | 摘要: | Objective: This study aimed to identify predictors of changes in diurnal cortisol patterns during the 8-month follow up period for young breast cancer survivors. Among the potential predictors were tumor size, lymph node metastasis, changes in sleep problems, habitual time of awakening and bedtime, physical activity levels, body mass index (BMI), and depressive levels across 8 months. Methods: The participants were 62 breast cancer women who were aged 40 years and below, and had completed active breast cancer treatment. The longitudinal data were collected at four points: baseline assessment (T0) and three follow-ups after baseline: T1 (in the 2nd month), T2 (in the 5th month), and T3 (in the 8th month). The participants collected their salivary cortisol at home at six time points: upon waking, 30 and 45. min after waking, and at 1200. h, 1700. h, and 2100. h. They also completed several questionnaires: the Medical Outcomes Study Sleep scale; the Beck Depression Inventory-II, physical activity levels on a 10-point scale, time of going to bed, time of awakening, and total sleep hours. Results: This study found that the main predictors of changes toward flatter diurnal cortisol patterns during the 8-month follow ups were greater tumor sizes, increases of BMI scores, and habitually later times of awakening. Conclusions: While greater tumor sizes represent biological vulnerability of disruption of cortisol circadian rhythm, maintaining an appropriate BMI and good sleep habits could be a protective factor for normal cortisol regulation, which likely helps to reduce early mortality in young breast cancer survivors. ? 2014 Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84922795918&doi=10.1016%2fj.psyneuen.2014.12.014&partnerID=40&md5=765d3987267f1862b22d6c3ff9dd4e6d https://scholars.lib.ntu.edu.tw/handle/123456789/477754 |
ISSN: | 0306-4530 | DOI: | 10.1016/j.psyneuen.2014.12.014 | SDG/關鍵字: | hydrocortisone; hydrocortisone; adult; Article; Beck Depression Inventory; body mass; breast cancer; cancer prognosis; cancer survivor; circadian rhythm; controlled study; depression; female; follow up; human; longitudinal study; lymph node metastasis; major clinical study; outcome assessment; physical activity; prospective study; questionnaire; rating scale; sleep time; sleep waking cycle; tumor volume; Breast Neoplasms; cancer staging; chemistry; circadian rhythm; insomnia; lifestyle; metabolism; motor activity; pathology; saliva; sleep; survivor; wakefulness; Adult; Breast Neoplasms; Circadian Rhythm; Female; Humans; Hydrocortisone; Life Style; Longitudinal Studies; Motor Activity; Neoplasm Staging; Saliva; Sleep; Sleep Initiation and Maintenance Disorders; Survivors; Tumor Burden; Wakefulness |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。