Intrinsic subtypes and tumor grades in breast cancer are associated with distinct 3-D power Doppler sonographic vascular features
Journal
European Journal of Radiology
Journal Volume
83
Journal Issue
8
Pages
1368-1374
Date Issued
2014
Author(s)
Abstract
Purpose This study aimed to investigate the three-dimensional (3-D) power Doppler ultrasonographic (PDUS) vascular features of breast carcinoma according to intrinsic subtypes, nodal stage, and tumor grade. Materials and methods Total 115 receiving mastectomy breast carcinomas (mean size, 2.5 cm; range, 0.7-6.5 cm), including 102 invasive ductal carcinomas (IDC), 10 ductal carcinomas in situ (DCIS), and 3 invasive lobular carcinomas (ILC) diagnosed after mastectomy, were used in this retrospective study. Sixty IDC had nodal status and histopathologic tumor grades available for analysis. Vascular features, including number of vascular trees (NV), longest path length (LPL), total vessel length (TVL), number of bifurcations (NB), distance metric (DM), inflection count metric (ICM), vessel diameter (VD), and vessel-to-volume ratio (VVR) were extracted using 3-D thinning method. The Mann-Whitney U test, Student's t-test, one-way ANOVA, and Kruskal-Wallis test were performed as appropriate. Results There was no significant difference of vascular features among IDC, DCIS and ILC. Except VD, vascular features in luminal type were significantly lower compared to HER2-enriched or triple negative types (p < 0.05). Compared to ER+ (estrogen receptor positive) tumors, all features in ER- (estrogen receptor negative) tumors were significantly higher (p < 0.01). Despite some significantly higher vascular features in high grade IDC compared to low and intermediate grade, there was no significant correlation between vascular features and nodal stages. Conclusion Differences in 3-D PDUS vascular features among intrinsic types of IDC are attributed to their ER status. Vascular features extracted by 3-D PDUS correlate with tumor grades but not nodal stage in IDC. ? 2014 Elsevier Ireland Ltd.
SDGs
Other Subjects
epidermal growth factor receptor 2; adult; aged; article; blood vessel diameter; breast carcinoma; cancer classification; cancer grading; cancer size; Doppler echography; estrogen receptor negative breast cancer; female; histopathology; human; intraductal carcinoma; major clinical study; mastectomy; priority journal; three dimensional imaging; triple negative breast cancer; breast tumor; cancer staging; Doppler flowmetry; echography; echomammography; intraductal carcinoma; lung carcinoma; lymph node metastasis; middle aged; Paget nipple disease; pathology; retrospective study; three dimensional imaging; vascularization; very elderly; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Female; Humans; Imaging, Three-Dimensional; Lymphatic Metastasis; Middle Aged; Neoplasm Grading; Neoplasm Staging; Retrospective Studies; Ultrasonography, Doppler; Ultrasonography, Mammary
Publisher
Elsevier Ireland Ltd
Type
journal article